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一例增生性皮肤利什曼病。

Exuberant case of verrucous cutaneous leishmaniasis.

机构信息

Hospital Universitário Professor Edgard Santos, Universidade Federal da Bahia, Salvador, BA, Brazil.

Hospital Universitário Professor Edgard Santos, Universidade Federal da Bahia, Salvador, BA, Brazil.

出版信息

An Bras Dermatol. 2022 Jan-Feb;97(1):89-92. doi: 10.1016/j.abd.2020.11.011. Epub 2021 Nov 26.

DOI:10.1016/j.abd.2020.11.011
PMID:34839986
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8799843/
Abstract

Cutaneous leishmaniasis represents a public health problem that affects 85 countries. It is an endemic disease in Brazil, having an important socioeconomic impact. An exuberant case of cutaneous leishmaniasis is reported herein. A 28-year-old male patient with Down syndrome had had verrucous plaques on the back for over a year, with progressive growth. PCR of a lesion sample was positive for Leishmania braziliensis. The patient's condition was classified as atypical cutaneous leishmaniasis. He was successfully treated with amphotericin B and miltefosine. The treatment remains a challenge, given the toxicity and low cure rate of the currently recommended drugs.

摘要

皮肤利什曼病是一个影响 85 个国家的公共卫生问题。它是巴西的地方性疾病，具有重要的社会经济影响。本文报告了一例丰富的皮肤利什曼病病例。一名 28 岁的唐氏综合征男性患者背部有疣状斑块，且不断增大，已超过一年。病变样本的 PCR 检测对巴西利什曼原虫呈阳性。患者的病情被归类为非典型皮肤利什曼病。他成功地接受了两性霉素 B 和米替福新治疗。鉴于目前推荐药物的毒性和低治愈率，治疗仍然是一个挑战。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/194d/8799843/ea496b3f37ca/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/194d/8799843/b7a355945b5b/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/194d/8799843/4975ee581d31/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/194d/8799843/536ef459720e/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/194d/8799843/fd35c2b53f25/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/194d/8799843/ea496b3f37ca/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/194d/8799843/b7a355945b5b/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/194d/8799843/4975ee581d31/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/194d/8799843/536ef459720e/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/194d/8799843/fd35c2b53f25/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/194d/8799843/ea496b3f37ca/gr5.jpg

相似文献

1
Exuberant case of verrucous cutaneous leishmaniasis.一例增生性皮肤利什曼病。
An Bras Dermatol. 2022 Jan-Feb;97(1):89-92. doi: 10.1016/j.abd.2020.11.011. Epub 2021 Nov 26.
2
Use of liposomal amphotericin B in disseminated cutaneous leishmaniasis caused by Leishmania braziliensis in a pediatric patient with Down syndrome.巴西利什曼原虫引起的播散性皮肤利什曼病合并唐氏综合征患儿应用脂质体两性霉素 B 治疗
Rev Peru Med Exp Salud Publica. 2023 Jan-Mar;40(1):94-98. doi: 10.17843/rpmesp.2023.401.11481. Epub 2023 Jun 23.
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Failure of Liposomal-amphotericin B Treatment for New World Cutaneous Leishmaniasis due to Leishmania braziliensis.脂质体两性霉素B治疗巴西利什曼原虫引起的新大陆皮肤利什曼病失败
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Clinical complexity of Leishmania (Viannia) braziliensis infections amongst travelers.利什曼原虫（Viannia）巴西利ensis 感染旅行者的临床复杂性。
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Am J Trop Med Hyg. 2021 May 10;105(1):142-143. doi: 10.4269/ajtmh.20-1642.
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In vitro miltefosine and amphotericin B susceptibility of strains and clinical isolates of Leishmania species endemic in Brazil that cause tegumentary leishmaniasis.在巴西流行的引起皮肤利什曼病的利什曼原虫种的株系和临床分离株的米替福新和两性霉素 B 的体外敏感性。
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[Liposomal amphotericin B treatment of cutaneous leishmaniasis caused by L. braziliensis: an imported case report].[脂质体两性霉素B治疗巴西利什曼原虫引起的皮肤利什曼病：1例输入性病例报告]
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Successful liposomal amphotericin B treatment of Leishmania braziliensis cutaneous leishmaniasis.脂质体两性霉素B成功治疗巴西利什曼原虫皮肤利什曼病。
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Mucosal relapse one year after complete remission of cutaneous sporotrichoid leishmaniasis due to Leishmania braziliensis.巴西利什曼原虫所致皮肤孢子丝菌样利什曼病完全缓解一年后出现黏膜复发。
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[Leishmania braziliensis: report of a pediatric imported case with response to liposomal amphotericin B].[巴西利什曼原虫：1例对脂质体两性霉素B有反应的儿科输入性病例报告]
Actas Dermosifiliogr. 2007 Jan-Feb;98(1):42-4.

本文引用的文献

1
Disseminated leishmaniasis: clinical, pathogenic, and therapeutic aspects.播散性利什曼病：临床、致病及治疗方面
An Bras Dermatol. 2019 Jan-Feb;94(1):9-16. doi: 10.1590/abd1806-4841.20198775.
2
Underlying factors of recurrent infections in patients with down syndrome.唐氏综合征患者反复感染的潜在因素。
North Clin Istanb. 2018 Jan 29;5(2):163-168. doi: 10.14744/nci.2017.69379. eCollection 2018.
3
Miltefosine in the treatment of cutaneous leishmaniasis caused by Leishmania braziliensis in Brazil: a randomized and controlled trial.
米替福新治疗巴西利什曼原虫引起的皮肤利什曼病：一项随机对照试验。
PLoS Negl Trop Dis. 2010 Dec 21;4(12):e912. doi: 10.1371/journal.pntd.0000912.
4
Atypical manifestations of tegumentary leishmaniasis in a transmission area of Leishmania braziliensis in the state of Bahia, Brazil.巴西巴伊亚州巴西利什曼原虫传播地区皮肤利什曼病的非典型表现
Trans R Soc Trop Med Hyg. 2009 Jul;103(7):712-5. doi: 10.1016/j.trstmh.2009.04.019. Epub 2009 May 28.