鸢尾素作为严重甲状腺功能减退患者心肌损伤相关的潜在生物标志物。
Irisin as a Potential Biomarker Associated with Myocardial Injuries in Patients with Severe Hypothyroidism.
作者信息
Yao Zhi, Ding Xiaoyu, Gao Xia, Yang Ning, Jia Yumei, Liu Jia, Wang Guang
机构信息
Department of Endocrinology, Beijing Chaoyang Hospital, Capital Medical University, Beijing 100020, China.
出版信息
Int J Endocrinol. 2021 Nov 18;2021:3116068. doi: 10.1155/2021/3116068. eCollection 2021.
OBJECTIVE
Irisin, a novel myokine, has recently been considered to produce a cardioprotective effect. Potential biomarkers for myocardial injuries in patients with severe hypothyroidism have yet to be identified. We aimed to investigate whether serum irisin may serve as a promising biomarker for early detecting the myocardial injuries in patients with severe hypothyroidism.
METHODS
This cross-sectional study comprised 25 newly diagnosed drug-naive patients with severe primary hypothyroidism and 17 age- and sex-matched healthy controls. Circulating irisin levels and cardiac magnetic resonance (CMR) were evaluated in each participant. Left ventricular (LV) myocardial injuries were detected by CMR-based T1 mapping technique using a modified look-locker inversion recovery (MOLLI) sequence, which is quantified as native T1 values.
RESULTS
Compared with healthy controls, the severe hypothyroidism group had significantly lower levels of serum irisin, especially those with pericardial effusion ( < 0.05). The severe hypothyroidism subjects exhibited lower peak filling rates (PFRs) and higher native myocardial T1 values than controls ( < 0.05). Additionally, the ROC analysis displayed that the sensitivity and specificity of serum irisin for diagnosing pericardial effusion in patients with severe hypothyroidism were 73.3% and 100.0%, respectively. The AUC was 0.920 (0.861-1.000) ( < 0.001). The cutoff value was 36.94 ng/mL. Moreover, the results in subgroup analysis revealed that the native T1 values of the low-irisin group were significantly higher than that of the high-irisin group ( < 0.05). According to multivariate linear regression analysis, serum irisin concentrations were negatively and independently correlated with native myocardial T1 values after adjustment for age, sex, and other conventional confounding factors ( = -1.473, < 0.05).
CONCLUSIONS
Irisin may be a potential biomarker for predicting myocardial injuries in patients with severe hypothyroidism.
目的
鸢尾素是一种新型的肌动蛋白，最近被认为具有心脏保护作用。严重甲状腺功能减退患者心肌损伤的潜在生物标志物尚未确定。我们旨在研究血清鸢尾素是否可作为早期检测严重甲状腺功能减退患者心肌损伤的有前景的生物标志物。
方法
这项横断面研究包括25例新诊断的未接受过药物治疗的严重原发性甲状腺功能减退患者和17例年龄和性别匹配的健康对照者。对每位参与者评估循环鸢尾素水平和心脏磁共振成像（CMR）。采用改良的Look-Locker反转恢复（MOLLI）序列，通过基于CMR的T1映射技术检测左心室（LV）心肌损伤，其量化为固有T1值。
结果
与健康对照者相比，严重甲状腺功能减退组血清鸢尾素水平显著降低，尤其是有心包积液的患者（<0.05）。严重甲状腺功能减退受试者的峰值充盈率（PFRs）低于对照组，固有心肌T1值高于对照组（<0.05）。此外，ROC分析显示，血清鸢尾素诊断严重甲状腺功能减退患者心包积液的敏感性和特异性分别为73.3%和100.0%。曲线下面积（AUC）为0.920（0.861 - 1.000）（<0.001）。截断值为36.94 ng/mL。此外，亚组分析结果显示，低鸢尾素组的固有T1值显著高于高鸢尾素组（<0.05）。根据多变量线性回归分析，在调整年龄、性别和其他传统混杂因素后，血清鸢尾素浓度与固有心肌T1值呈负相关且独立相关（=-1.473，<0.05）。
结论
鸢尾素可能是预测严重甲状腺功能减退患者心肌损伤的潜在生物标志物。
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