纤维连接蛋白 III 型结构域包含蛋白 5 在心血管和代谢疾病中的作用：一个有前途的生物标志物和治疗靶点。
Fibronectin type III domain-containing 5 in cardiovascular and metabolic diseases: a promising biomarker and therapeutic target.
机构信息
Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan, 430060, China.
Hubei Key Laboratory of Metabolic and Chronic Diseases, Wuhan, 430060, China.
出版信息
Acta Pharmacol Sin. 2021 Sep;42(9):1390-1400. doi: 10.1038/s41401-020-00557-5. Epub 2020 Nov 19.
Abstract
Cardiovascular and metabolic diseases are the leading causes of death and disability worldwide and impose a tremendous socioeconomic burden on individuals as well as the healthcare system. Fibronectin type III domain-containing 5 (FNDC5) is a widely distributed transmembrane glycoprotein that can be proteolytically cleaved and secreted as irisin to regulate glycolipid metabolism and cardiovascular homeostasis. In this review, we present the current knowledge on the predictive and therapeutic role of FNDC5 in a variety of cardiovascular and metabolic diseases, such as hypertension, atherosclerosis, ischemic heart disease, arrhythmia, metabolic cardiomyopathy, cardiac remodeling, heart failure, diabetes mellitus, and obesity.
摘要
心血管和代谢疾病是全球范围内导致死亡和残疾的主要原因，给个人和医疗保健系统带来了巨大的社会经济负担。纤维连接蛋白结构域包含 5（FNDC5）是一种广泛分布的跨膜糖蛋白，可被蛋白水解酶切割并分泌为鸢尾素，以调节糖脂代谢和心血管稳态。在这篇综述中，我们介绍了 FNDC5 在各种心血管和代谢疾病中的预测和治疗作用的最新知识，如高血压、动脉粥样硬化、缺血性心脏病、心律失常、代谢性心肌病、心脏重构、心力衰竭、糖尿病和肥胖症。
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