富血小板血浆微针与氨甲环酸微针对黄褐斑的治疗效果比较
Therapeutic Effect of Microneedling with Platelet-rich Plasma Versus Microneedling with Tranexamic Acid for Melasma.
作者信息
Gharib Khaled, Mostafa Fawzia Farag, Ghonemy Soheir
机构信息
All authors are with the Department of Dermatology, Venerology and Andrology, Faculty of Medicine, Zagazig University, Zagazig, Egypt.
出版信息
J Clin Aesthet Dermatol. 2021 Aug;14(8):44-48. Epub 2021 Aug 1.
BACKGROUND
Melasma is a chronic acquired focal pigment disorder showing symmetrical hyperpigmentation or hypermelanosis of photoexposed areas on the face. Tranexamic acid (TXA) is a treatment for melasma. The regression of melasma after platelet-rich-plasma (PRP) treatment is an interesting finding.
OBJECTIVE
We investigated the effect of microneedling followed by PRP versus microneedling followed by tranexamic acid in the treatment of patients with melasma.
METHODS
The study included 26 patients with melasma divided into two groups of 13 patients each. Group 1 was treated with microneedling and PRP, and Group 2 was treated with microneedling and tranexamic acid.
RESULTS
The response to treatment was assessed using the Melasma Area and Severity Index scoring system before and after treatment. At the start of the study and at the first session, there were no statistically significant differences (>0.05). At the second and third treatment sessions, there were statistically significant differences (<0.05). There were no statistically significant differences between the two groups regarding side effects of pain, erythema and postinflammatory hyperpigmentation.
CONCLUSION
Microneedling with PRP offers better results than microneedling with TXA in treating melasma.
背景
黄褐斑是一种慢性获得性局限性色素沉着紊乱疾病，表现为面部光照暴露部位的对称性色素沉着或色素沉着过度。氨甲环酸（TXA）是一种治疗黄褐斑的方法。富血小板血浆（PRP）治疗后黄褐斑的消退是一个有趣的发现。
目的
我们研究了微针联合PRP与微针联合氨甲环酸治疗黄褐斑患者的效果。
方法
该研究纳入了26例黄褐斑患者，分为两组，每组13例。第1组接受微针联合PRP治疗，第2组接受微针联合氨甲环酸治疗。
结果
采用黄褐斑面积和严重程度指数评分系统在治疗前后评估治疗反应。在研究开始时和第一次治疗时，无统计学显著差异（>0.05）。在第二次和第三次治疗时，有统计学显著差异（<0.05）。两组在疼痛、红斑和炎症后色素沉着等副作用方面无统计学显著差异。
结论
微针联合PRP治疗黄褐斑的效果优于微针联合TXA。
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