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本文引用的文献

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Factors influencing pre-injection aspiration for hyaluronic acid fillers: A systematic literature review and meta-analysis.影响透明质酸填充剂预注射抽吸的因素:系统文献回顾和荟萃分析。
Dermatol Ther. 2021 Jan;34(1):e14360. doi: 10.1111/dth.14360. Epub 2020 Oct 20.
2
Transvascular Hydrolysis of Hyaluronic Acid Filler With Hyaluronidase: An Ex Vivo Study.透明质酸酶对透明质酸填充剂的经血管水解作用:一项体外研究。
Dermatol Surg. 2021 Mar 1;47(3):370-372. doi: 10.1097/DSS.0000000000002773.
3
False Sense of Safety: Blunt Cannulas Cause the Majority of Severe Vascular Complications in Hyaluronic Acid Injection.安全感错觉:钝针导致透明质酸注射中大多数严重血管并发症。
Plast Reconstr Surg. 2020 Aug;146(2):240e-241e. doi: 10.1097/PRS.0000000000007022.
4
Hyperbaric Oxygen Treatment of Keratitis Following Facial Hyaluronic Acid Injection.面部透明质酸注射后角膜炎的高压氧治疗
Ochsner J. 2020 Summer;20(2):193-196. doi: 10.31486/toj.18.0133.
5
The Functional Anatomy of the Ophthalmic Angiosome and Its Implications in Blindness as a Complication of Cosmetic Facial Filler Procedures.眼血管分布区的功能解剖及其在美容面部填充物并发症导致失明中的意义。
Plast Reconstr Surg. 2020 Oct;146(4):745. doi: 10.1097/PRS.0000000000007155.
6
Central serous chorioretinopathy: An update on risk factors, pathophysiology and imaging modalities.中心性浆液性脉络膜视网膜病变:危险因素、发病机制和影像学检查方法的最新进展。
Prog Retin Eye Res. 2020 Nov;79:100865. doi: 10.1016/j.preteyeres.2020.100865. Epub 2020 May 11.
7
Vision Loss Associated with Hyaluronic Acid Fillers: A Systematic Review of Literature.与透明质酸填充物相关的视力丧失:文献系统评价。
Aesthetic Plast Surg. 2020 Jun;44(3):929-944. doi: 10.1007/s00266-019-01562-8. Epub 2019 Dec 10.
8
A Consensus on Minimizing the Risk of Hyaluronic Acid Embolic Visual Loss and Suggestions for Immediate Bedside Management.关于最小化透明质酸致栓塞性视力丧失风险的共识及即时床边管理建议。
Aesthet Surg J. 2020 Aug 14;40(9):1009-1021. doi: 10.1093/asj/sjz312.
9
Early ultrasound for diagnosis and treatment of vascular adverse events with hyaluronic acid fillers.早期超声用于透明质酸填充剂血管不良事件的诊断与治疗
J Am Acad Dermatol. 2023 Jan;88(1):79-85. doi: 10.1016/j.jaad.2019.07.032. Epub 2019 Jul 17.
10
Clinical Observations and the Anatomical Basis of Blindness After Facial Hyaluronic Acid Injection.面部透明质酸注射后失明的临床观察及解剖学基础
Aesthetic Plast Surg. 2019 Aug;43(4):1054-1060. doi: 10.1007/s00266-019-01374-w. Epub 2019 Apr 21.

透明质酸填充剂所致血管阻塞的管理指南

Guideline for the Management of Hyaluronic Acid Filler-induced Vascular Occlusion.

作者信息

Murray Gillian, Convery Cormac, Walker Lee, Davies Emma

机构信息

Dr. Murray is with Clinical Academic Kings College in London, England.

Dr. Convery is with The Ever Clinic in Glasgow, Scotland.

出版信息

J Clin Aesthet Dermatol. 2021 May;14(5):E61-E69. Epub 2021 May 1.

PMID:34188752
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8211329/
Abstract

Vascular occlusions can occur with injection of dermal fillers causing devastating outcomes for the patient. The occurrence, and subsequent management, of these negative outcomes is a source of significant stress to the aesthetic clinician. Complications management is an essential component of clinical practice and professionals must develop competence and confidence in the identification and effective treatment of a vascular occlusion. The relatively rare occurrence of a vascular occlusion mandates that learning must be largely through the study of theory in addition to the sharing of learning experiences within a collaborative clinical community. The delivery of optimal care begins with an understanding of the underlying pathophysiology and the ability to assess and elicit clinical signs. Establishing a clinical diagnosis, targeted therapy can commence in a timely fashion. This paper provides guidance on how to identify and manage a vascular occlusion caused by cross-linked hyaluronic acid. It provides a detailed description of the pathological process of tissue ischemia, and introduces identifiable stages which will help to determine the extent of ischemia and the time frame since ischemic onset. The stages are particularly important as they highlight when wound support may be needed.

摘要

注射真皮填充剂时可能会发生血管阻塞,给患者带来灾难性后果。这些负面结果的发生及后续处理,给美容临床医生带来了巨大压力。并发症管理是临床实践的重要组成部分,专业人员必须在识别和有效治疗血管阻塞方面培养能力和信心。血管阻塞相对罕见,这就要求除了在协作临床社区内分享学习经验外,还必须主要通过理论学习来掌握相关知识。提供最佳护理始于了解潜在的病理生理学以及评估和引出临床体征的能力。确立临床诊断后,即可及时开始针对性治疗。本文就如何识别和处理由交联透明质酸引起的血管阻塞提供指导。它详细描述了组织缺血的病理过程,并介绍了可识别的阶段,这将有助于确定缺血程度和缺血开始后的时间框架。这些阶段尤为重要,因为它们突出了何时可能需要伤口支持。