Pelusi Letizia, Mandatori Domitilla, Mastropasqua Leonardo, Agnifili Luca, Allegretti Marcello, Nubile Mario, Pandolfi Assunta
Department of Medical, Oral and Biotechnological Sciences, Center for Advanced Studies and Technology-CAST, StemTeCh Group, University G. D'Annunzio of Chieti-Pescara, 66100 Chieti, Italy.
Department of Medicine and Aging Science, Ophthalmology Clinic, University G. D'Annunzio of Chieti-Pescara, 66100 Chieti, Italy.
Pharmaceutics. 2023 Feb 13;15(2):625. doi: 10.3390/pharmaceutics15020625.
Nowadays, ocular drug delivery still remains a challenge, since the conventional dosage forms used for anterior and posterior ocular disease treatments, such as topical, systemic, and intraocular administration methods, present important limitations mainly related to the anatomical complexity of the eye. In particular, the blood-ocular barrier along with the corneal barrier, ocular surface, and lacrimal fluid secretion reduce the availability of the administered active compounds and their efficacy. These limitations have increased the need to develop safe and effective ocular delivery systems able to sustain the drug release in the interested ocular segment over time. In the last few years, thanks to the innovations in the materials and technologies employed, different ocular drug delivery systems have been developed. Therefore, this review aims to summarize the synthetic and natural drug-loaded ocular inserts, contacts, and intraocular lenses that have been recently developed, emphasizing the characteristics that make them promising for future ocular clinical applications.
如今，眼部药物递送仍然是一项挑战，因为用于治疗眼前段和眼后段疾病的传统剂型，如局部、全身和眼内给药方法，存在重要局限性，主要与眼睛的解剖复杂性有关。特别是，血眼屏障以及角膜屏障、眼表和泪液分泌会降低所给药活性化合物的可用性及其疗效。这些局限性增加了开发安全有效的眼部递送系统的需求，该系统能够随着时间的推移在感兴趣的眼段维持药物释放。在过去几年中，由于所采用材料和技术的创新，已开发出不同的眼部药物递送系统。因此，本综述旨在总结最近开发的合成和天然载药眼用插入物、隐形眼镜和人工晶状体，强调使其在未来眼部临床应用中具有前景的特性。
