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基于网络药理学的 抗胃癌作用的活性成分及机制研究

Network Pharmacology-Based Study on the Active Component and Mechanism of the Anti-Gastric-Cancer Effect of .

机构信息

The Third Hospital of Hebei Medical University, Pharmacy Department, Shijiazhuang, China.

The Third Hospital of Hebei Medical University, Department of Chinese Medicine, Shijiazhuang, China.

出版信息

J Healthc Eng. 2021 Nov 19;2021:3001131. doi: 10.1155/2021/3001131. eCollection 2021.

DOI:10.1155/2021/3001131
PMID:34840695
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8626172/
Abstract

BACKGROUND

is used in the clinical practice of traditional Chinese medicine to deal with gastric cancer. However, there are few studies on its precise mechanism.

METHOD

In this study, a network pharmacological approach was utilized to construct a molecular/target/pathway molecular regulatory network for the anti-gastric-cancer effect of . The active components of and their potential mechanisms were explored. Chemical components of the were identified through a database, and they were evaluated and screened based on oral bioavailability and drug similarity.

RESULTS

Genes related to gastric cancer were found in the Gene Expression Omnibus (GEO) database, and gene targets related to anti-gastric-cancer were chosen by comparison. Using annotation, visualization, and a comprehensive discovery database, the function and related pathways of target genes were analyzed and screened. Cytoscape software was utilized to construct a component/target/pathway network for the antitumor effect of . Finally, 6 drug ingredients and 29 target genes related to gastric cancer were detected. IL-17 signaling pathway, NF-kappa B signaling pathway, and other signaling pathways were significantly enriched. Many signaling pathways that directly act on tumors and indirect pathways inhibit the development of gastric cancer.

CONCLUSION

This study provides a scientific basis for further elucidating the mechanism of the anti-gastric-cancer effect of .

摘要

背景

在中医临床实践中用于治疗胃癌。然而，关于其确切机制的研究较少。

方法

本研究采用网络药理学方法构建了 治疗胃癌作用的分子/靶标/途径分子调控网络。探讨了 的活性成分及其潜在机制。通过数据库鉴定 的化学组成，并基于口服生物利用度和药物相似性进行评估和筛选。

结果

在基因表达综合数据库（GEO）中发现了与胃癌相关的基因，并通过比较选择了与抗胃癌相关的基因靶标。使用注释、可视化和综合发现数据库分析和筛选靶基因的功能和相关途径。利用 Cytoscape 软件构建了 抗肿瘤作用的成分/靶标/途径网络。最后，检测到 6 种药物成分和 29 个与胃癌相关的靶基因。IL-17 信号通路、NF-kappa B 信号通路等信号通路显著富集。许多直接作用于肿瘤的信号通路和间接通路抑制胃癌的发展。

结论

本研究为进一步阐明 治疗胃癌的作用机制提供了科学依据。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f213/8626172/f51af050e672/JHE2021-3001131.008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f213/8626172/94c34b36c19e/JHE2021-3001131.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f213/8626172/7c7170687f88/JHE2021-3001131.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f213/8626172/460e6c37db51/JHE2021-3001131.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f213/8626172/5b8649ab0b64/JHE2021-3001131.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f213/8626172/97b0b5d07db0/JHE2021-3001131.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f213/8626172/57347de9de58/JHE2021-3001131.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f213/8626172/0ee465f2bac1/JHE2021-3001131.007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f213/8626172/f51af050e672/JHE2021-3001131.008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f213/8626172/94c34b36c19e/JHE2021-3001131.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f213/8626172/7c7170687f88/JHE2021-3001131.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f213/8626172/460e6c37db51/JHE2021-3001131.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f213/8626172/5b8649ab0b64/JHE2021-3001131.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f213/8626172/97b0b5d07db0/JHE2021-3001131.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f213/8626172/57347de9de58/JHE2021-3001131.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f213/8626172/0ee465f2bac1/JHE2021-3001131.007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f213/8626172/f51af050e672/JHE2021-3001131.008.jpg

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