Antakle Mohamad, Alshaghel Mohammed Moutaz, Ghannam Ghina, Al-Ibraheem Mais, Shehade Linda, Agha Sarab, Etr Aladdin
Faculty of Medicine, Aleppo University, Aleppo, Syria.
Department of Pathology, Faculty of Medicine, Aleppo University, Aleppo, Syria.
Ann Med Surg (Lond). 2021 Oct 30;71:102992. doi: 10.1016/j.amsu.2021.102992. eCollection 2021 Nov.
and importance: Leiomyosarcoma is a rare aggressive soft-tissue malignancy typically originating from embryonic mesoderm or mesenchymal cell lines in smooth muscles.Leiomyosarcoma of the skin is termed as "Dermal Leiomyosarcoma", and is categorized into two subdivisions; superficial cutaneous and deep subcutaneous.Both types begin either as primary lesions or metastatic lesions from distant sites.
We report the case of a 60-year-old male patient with Primary Cutaneous Leiomyosarcoma (PCL) located in the left iliac regionHis history is insignificant and he has no family or genetic history of leiomyosarcoma. The lesion was itchy without any other symptoms and existed 20 years before our evaluation.A biopsy from the nodule was performed and sent to the pathology department, where the section was stained with smooth muscle actin stain (SMA) and the result was positive.We referred the patient to a surgeon to excise the nodule. The lesion was excised with a 3cm safety margin, the eradication includes also the of the major iliac muscle.After one year of follow-up there was no metastasis nor recurrence.
Primary Cutaneous Leiomyosarcoma is a very rare malignancy and it is hard to diagnose without biopsy and pathological examination.
及其重要性：平滑肌肉瘤是一种罕见的侵袭性软组织恶性肿瘤，通常起源于胚胎中胚层或平滑肌中的间充质细胞系。皮肤平滑肌肉瘤被称为“皮肤平滑肌肉瘤”，并分为两个亚类；浅表性皮肤型和深部皮下型。这两种类型均起始于原发性病变或远处部位的转移性病变。
我们报告一例60岁男性患者，患有位于左髂区的原发性皮肤平滑肌肉瘤（PCL）。他的病史无特殊，且无平滑肌肉瘤的家族史或遗传史。该病变有瘙痒感，无任何其他症状，在我们评估前已存在20年。对结节进行了活检并送至病理科，切片用平滑肌肌动蛋白染色（SMA），结果为阳性。我们将患者转诊给外科医生以切除结节。病变以3厘米的安全切缘切除，切除范围还包括主要的髂肌。随访一年后，无转移及复发。
原发性皮肤平滑肌肉瘤是一种非常罕见的恶性肿瘤，未经活检和病理检查很难诊断。
