肺结核患者痰液中血清前列腺素E水平与抗酸杆菌阳性程度之间的关联。
Association between serum PGE levels and degree of acid-fast bacilli positivity in sputum of pulmonary tuberculosis patients.
作者信息
Setiawan Herley Windo, Yudhawati Resti, Syafaah Irmi
机构信息
Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, Universitas Airlangga - Dr. Soetomo General Academic Hospital, Surabaya, Indonesia.
Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, Universitas Airlangga - Universitas Airlangga Teaching Hospital, Surabaya, Indonesia.
出版信息
Ann Med Surg (Lond). 2021 Nov 3;71:103008. doi: 10.1016/j.amsu.2021.103008. eCollection 2021 Nov.
BACKGROUND
that infected apoptotic macrophages is triggered by PGE. Apoptosis suppresses the growth of bacteria, which is shown in the results of acid-fast bacilli (AFB) in the sputum that becomes a marker of the number of bacteria.
OBJECTIVE
Analyzing the association between serum PGE levels and the positivity of AFB in the sputum of tuberculosis patients.
METHODS
A cross-sectional study was carried out from August 2019-July 2020. Serum PGE levels and AFB levels in sputum were collected from participants. Data analysis used the Chi-square test and Spearman's correlation with < 0.05.
RESULTS
The average participants' serum PGE levels were 446.37 ± 510.27 pg/ml, with a median value of 216.95 pg/ml. Most participants had normal serum PGE levels (62.9%). Most participants had a high positivity of AFB in sputum (58.1%). Analysis of the association between serum PGE levels and the degree of AFB positivity in sputum obtained = -0.036 and -value = 0.780.
CONCLUSION
There is a weak negative association between serum PGE levels and the degree of AFB positivity in sputum but not statistically significant.
背景
感染性凋亡巨噬细胞由前列腺素E（PGE）触发。凋亡可抑制细菌生长，这在痰中抗酸杆菌（AFB）的检测结果中得到体现，痰中抗酸杆菌数量成为细菌数量的一个指标。
目的
分析肺结核患者血清PGE水平与痰中AFB阳性之间的关联。
方法
于2019年8月至2020年7月开展一项横断面研究。收集参与者的血清PGE水平和痰中AFB水平。数据分析采用卡方检验和Spearman相关性分析，P<0.05。
结果
参与者血清PGE水平平均值为446.37±510.27 pg/ml，中位数为216.95 pg/ml。大多数参与者血清PGE水平正常（62.9%）。大多数参与者痰中AFB阳性率较高（58.1%）。血清PGE水平与痰中AFB阳性程度之间的关联分析得出r = -0.036，P值 = 0.780。
结论
血清PGE水平与痰中AFB阳性程度之间存在微弱的负相关，但无统计学意义。
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