肺结核患者血清维生素D水平与细菌载量的关联
Association of Serum Vitamin D Levels with Bacterial Load in Pulmonary Tuberculosis Patients.
作者信息
Yuvaraj B, Sridhar M G, Kumar S Vinod, Kadhiravan T
机构信息
Department of Biochemistry, Jawaharlal Institute of Postgraduate Medical Education & Research (JIPMER), Pondicherry, India.
Department of Pulmonary Medicine, Jawaharlal Institute of Postgraduate Medical Education & Research (JIPMER), Pondicherry, India.
出版信息
Tuberc Respir Dis (Seoul). 2016 Jul;79(3):153-7. doi: 10.4046/trd.2016.79.3.153. Epub 2016 Jul 1.
BACKGROUND
Vitamin D is known to have diverse effects on various systems in the body. There is evidence to suggest that a link exists between the serum vitamin D status and tuberculosis. The present study was designed to assess the alterations in serum 25-hydroxyvitamin D levels in newly diagnosed sputum acid fast bacilli (AFB) positive pulmonary tuberculosis patients and to study the association, if any, between serum vitamin D levels and different levels of sputum smear positivity.
METHODS
Serum 25-hydroxyvitamin D levels were estimated in 65 sputum AFB positive pulmonary tuberculosis patients and 65 age and gender-matched healthy controls.
RESULTS
The levels of serum 25 hydroxy-vitamin D in tuberculosis patients were not statistically different from the levels of serum 25 hydroxy-vitamin D in healthy controls. However, among patients with pulmonary tuberculosis, there was a significant negative correlation between the levels of serum 25 hydroxy-vitamin D and levels of sputum positivity.
CONCLUSION
Serum vitamin D levels negatively correlates with bacterial load in patients with active pulmonary tuberculosis.
背景
已知维生素D对人体的各个系统有多种作用。有证据表明血清维生素D状态与结核病之间存在联系。本研究旨在评估新诊断的痰涂片抗酸杆菌（AFB）阳性肺结核患者血清25-羟维生素D水平的变化，并研究血清维生素D水平与不同程度痰涂片阳性之间是否存在关联。
方法
对65例痰AFB阳性肺结核患者和65例年龄及性别匹配的健康对照者进行血清25-羟维生素D水平测定。
结果
肺结核患者血清25-羟维生素D水平与健康对照者血清25-羟维生素D水平无统计学差异。然而，在肺结核患者中，血清25-羟维生素D水平与痰菌阳性程度之间存在显著负相关。
结论
活动性肺结核患者血清维生素D水平与细菌载量呈负相关。
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