Kaul Neha, Laing Joshua, Nicolo John-Paul, Nation Judy, Kwan Patrick, O'Brien Terence J
Department of Allied Health (Clinical Nutrition) (NK), Royal Melbourne Hospital; Department of Nutrition and Dietetics, (NK) Alfred Hospital; Departments of Medicine and Neurology (NK, J-PN, JN, PK, TJO), Royal Melbourne Hospital, University of Melbourne; and Departments of Neurosciences and Neurology (NK, JL, J-PN, PK, TJO), Alfred Hospital and Monash University, Melbourne, Australia.
Neurol Clin Pract. 2021 Oct;11(5):438-444. doi: 10.1212/CPJ.0000000000001009.
Ketogenic diet therapy can be used as an adjuvant treatment of super-refractory status epilepticus (SRSE). However, the drug and metabolic interactions with concomitant treatments present a challenge for clinicians. In this review, we focus on the practical considerations of implementing ketogenic dietary therapy in the acute setting, including the dietary composition, potential drug-diet interactions, and monitoring during ketogenic treatment.
This report describes the ketogenic diet therapy protocol implemented for the treatment of SRSE and a review of the current evidence to support clinical practice.
The control of SRSE is critical in reducing morbidity and mortality. There is emerging evidence that ketogenic diet may be a safe and effective treatment option for these patients.
生酮饮食疗法可作为超难治性癫痫持续状态（SRSE）的辅助治疗方法。然而，其与同时进行的治疗之间的药物和代谢相互作用给临床医生带来了挑战。在本综述中，我们重点关注在急性情况下实施生酮饮食疗法的实际考量，包括饮食组成、潜在的药物 - 饮食相互作用以及生酮治疗期间的监测。
本报告描述了为治疗SRSE实施的生酮饮食疗法方案，并对支持临床实践的现有证据进行了综述。
控制SRSE对于降低发病率和死亡率至关重要。越来越多的证据表明，生酮饮食可能是这些患者安全有效的治疗选择。
