Binghamton University, Binghamton, NY, USA.
Ann Hum Biol. 2021 Dec;48(7-8):535-539. doi: 10.1080/03014460.2021.2010803. Epub 2021 Dec 20.
Vaping, the use of an electronic device to deliver a drug-infused aerosol has become an increasingly popular way to consume nicotine since its introduction to the market in the early 2000s. Despite the differences in consumption patterns relative to combustible tobacco, the impact of ad libitum nicotine vaping on cardiovascular response has not been thoroughly studied.
This research was conducted on vapers ( = 17) and smokers ( = 14) who represent a subsample of a larger study that explored the relationship between nicotine use, activities of daily living and 24-hour cardiovascular response using Spacelabs ambulatory blood pressure monitors. These data were analysed via ANOVA models and t-tests using SPSS 25.0 for Macintosh.
Vapers consumed nicotine significantly more frequently than did smokers, at 48.2% and 18.1% of every 15-minute waking measurement, respectively ( = 0.000). The act of nicotine consumption, rather than the mode of delivery, was significantly associated with increases in systolic, diastolic, mean arterial pressure, and heart rate readings. There was no difference in the mean amplitude of response to nicotine between vapers and smokers.
This study's strong statistical findings, visually evident on ambulatory blood pressure monitor reports, demonstrated that ad libitum nicotine consumption has an acute, dose-dependent effect on cardiovascular response regardless of whether it is smoked or vaped. However, since vapers consumed nicotine more frequently, future studies should be conducted with larger sample sizes, and controlled for age and comorbidities to improve statistical strength.
This pilot study reveals that, when consumption is documented and measured, vaping has unique and potentially harmful effects on blood pressure, pulse, and mean arterial pressure. Because nicotine is consumed for much longer stretches, vapers have fewer rest periods between nicotine doses.
自 21 世纪初电子烟问世以来，作为一种吸食含有药物气溶胶的电子设备，其已成为尼古丁消费的一种日益流行的方式。尽管与可燃烟草相比，吸烟方式存在差异，但目前尚未对随意尼古丁蒸气吸入对心血管反应的影响进行全面研究。
本研究的对象为蒸气烟使用者（ = 17）和吸烟者（ = 14），他们是一项更大规模研究的子样本，该研究探索了尼古丁使用、日常生活活动与 24 小时心血管反应之间的关系，使用的是 Spacelabs 动态血压监测仪。使用 SPSS 25.0 for Macintosh 对这些数据进行方差分析模型和 t 检验分析。
蒸气烟使用者吸食尼古丁的频率明显高于吸烟者，分别为每 15 分钟清醒测量的 48.2%和 18.1%（ = 0.000）。尼古丁的摄入行为，而不是其传递方式，与收缩压、舒张压、平均动脉压和心率读数的增加显著相关。蒸气烟使用者和吸烟者之间对尼古丁的平均反应幅度没有差异。
本研究的统计结果很强有力，从动态血压监测报告中可以明显看出，随意摄入尼古丁会对心血管反应产生急性、剂量依赖性的影响，无论其是通过吸烟还是蒸气吸入。然而，由于蒸气烟使用者吸食尼古丁的频率更高，因此未来的研究应该扩大样本量，并控制年龄和合并症等因素，以提高统计效力。
本初步研究揭示了，当记录和测量吸烟行为时，蒸气吸入对血压、脉搏和平均动脉压有独特且潜在有害的影响。由于尼古丁的吸食时间更长，蒸气烟使用者在尼古丁剂量之间的休息时间更少。
