Garibaldi B A, Fox J G, Otto G, Murphy J C, Pecquet-Goad M E
Massachusetts Institute of Technology, Cambridge, MA 02139.
Lab Anim Sci. 1987 Dec;37(6):769-72.
A nine year retrospective study of hematuria in 14 New Zealand White rabbits was conducted to classify possible etiologies of this clinical finding. Physical examination, laboratory tests, radiography and postmortem examination were utilized in most cases to verify the presence of hematuria and to determine its etiology. Uterine adenocarcinoma was diagnosed in two rabbits. Three rabbits had uterine polyps with hemorrhage. Renal infarction with hemorrhage was diagnosed in three rabbits. Urolithiasis with secondary urethral obstruction and hemorrhagic cystitis was identified as the cause of hematuria in four rabbits. Other causes of hematuria included chronic cystitis, disseminated intravascular coagulation, bladder polyps and pyelonephritis. Hematuria of undetermined origin was observed in one rabbit. This last [corrected] case was negative for both blood and porphyrin in the urine, but positive for excess levels of urobilin, the oxidative product of urobilinogen. This case illustrates that hyperpigmented urine should be a rule out in all cases of suspected hematuria in rabbits.
对14只新西兰白兔的血尿情况进行了一项为期九年的回顾性研究，以对这一临床发现的可能病因进行分类。在大多数情况下，通过体格检查、实验室检查、放射照相和尸检来证实血尿的存在并确定其病因。两只兔子被诊断出患有子宫腺癌。三只兔子有伴有出血的子宫息肉。三只兔子被诊断出患有伴有出血的肾梗死。尿路结石伴继发性尿道梗阻和出血性膀胱炎被确定为四只兔子血尿的病因。血尿的其他病因包括慢性膀胱炎、弥散性血管内凝血、膀胱息肉和肾盂肾炎。在一只兔子中观察到来源不明的血尿。最后这例[纠正后]病例的尿液中血液和卟啉均为阴性，但尿胆素（尿胆原的氧化产物）水平过高呈阳性。该病例表明，在所有疑似兔子血尿的病例中，都应排除色素沉着过多的尿液。
