Department of Ophthalmology, Karadeniz Technical University, Faculty of Medicine, Tip Fakultesi, Goz Hastaliklari Klinigi, Farabi Caddesi, Trabzon 61080, Turkey.
Department of Anaesthesiology and Reanimation, Karadeniz Technical University, Faculty of Medicine, Trabzon, Turkey.
Photodiagnosis Photodyn Ther. 2022 Mar;37:102658. doi: 10.1016/j.pdpdt.2021.102658. Epub 2021 Nov 26.
To investigate the potential benefits and practicality of ultra - wide field (UWF) imaging and intravenous UWF fluorescein angiography (IV UWF - FA) in infants with retinopathy of prematurity (ROP) using an Optos® California device.
This retrospective study involved 46 infants with a history of ROP who underwent UWF imaging with or without IV UWF - FA. ROP characteristics were identified using UWF color imaging. Retinal vascular findings following treatment were also assessed at IV UWF - FA analysis. All imaging sessions were performed under topical anesthesia without sedation. Main outcomes were the appearance of ROP at UWF color imaging and IV UWF-FA analysis, including status of ROP, neovascularizations, presence of plus disease, retinal vascular details, and resolution after treatment.
Seven (three girls) of the 46 infants (22 girls) underwent IV UWF-FA. Twelve IV UWF-FA sessions were performed in total. The oldest infant during IV UWF-FA analysis was at 55 postmenstrual weeks. Clinical characteristics of disease were easily identified at UWF color imaging. IV UWF-FA images also clearly revealed non-perfused retinal areas, fluorescein leakage, macular edema, retinal vascular abnormalities, and the status of the peripheral vascular termini. Complications of IV UWF-FA occurred in one infant in the form of patchy yellow skin discoloration around the injection site which completely disappeared on the first day following the procedure.
Providing a high resolution panoramic view of the retina in a single image capture with no need for contact with the cornea appear to represent potential advantages of UWF imaging in infants with ROP. IV UWF-FA also seems to be a safe procedure which can be performed under topical anesthesia and that shows detailed retinal vascular alterations in patients with ROP.
使用 Optos® California 设备研究超广角（UWF）成像和静脉内 UWF 荧光素血管造影（IV UWF-FA）在早产儿视网膜病变（ROP）婴儿中的潜在益处和实用性。
本回顾性研究纳入了 46 例有 ROP 病史的婴儿，他们接受了 UWF 成像检查，其中一些婴儿还接受了 IV UWF-FA 检查。使用 UWF 彩色成像识别 ROP 特征。在 IV UWF-FA 分析中，还评估了治疗后视网膜血管的发现。所有成像检查均在局部麻醉下进行，无需镇静。主要结果是 UWF 彩色成像和 IV UWF-FA 分析中 ROP 的表现，包括 ROP 的状态、新生血管形成、存在加号疾病、视网膜血管细节以及治疗后的消退情况。
46 例婴儿中有 7 例（3 名女孩）（22 名女孩）接受了 IV UWF-FA 检查。总共进行了 12 次 IV UWF-FA 检查。进行 IV UWF-FA 分析时，最大的婴儿为 55 周龄。UWF 彩色成像可轻松识别疾病的临床特征。IV UWF-FA 图像还清晰地显示了无灌注视网膜区域、荧光素渗漏、黄斑水肿、视网膜血管异常以及周边血管末梢的状态。IV UWF-FA 检查仅在 1 例婴儿中出现并发症，表现为注射部位周围出现片状黄色皮肤变色，该症状在检查后第一天完全消失。
UWF 成像在 ROP 婴儿中提供了视网膜的高分辨率全景视图，单次图像捕获无需接触角膜，这似乎是其潜在优势。IV UWF-FA 似乎也是一种安全的检查方法，可在局部麻醉下进行，并可显示 ROP 患者的详细视网膜血管改变。
