Department of Ophthalmology, Haseki Training and Research Hospital, Sultangazi, Istanbul 34265, Turkey.
Department of Obstetrics and Gynecology, Recep Tayyip Erdogan University Faculty of Medicine, Rize, Turkey.
Photodiagnosis Photodyn Ther. 2022 Mar;37:102654. doi: 10.1016/j.pdpdt.2021.102654. Epub 2021 Nov 26.
To compare the meibomian glands (MG), non-invasive tear film break-up time (NITBUT), and corneal and anterior segment measurements in patients with polycystic ovary syndrome and healthy women.
The study included 66 polycystic ovarian syndrome (PCOS) patients and 42 healthy volunteers aged 18-35 years. The first and average NITBUT, MG loss, mean keratometry (Km), central (CCT) and thinnest (TCT) corneal thicknesses, anterior chamber depth (ACD), anterior chamber volume (ACV), irido-corneal angle (ICA), corneal volume (CV) and Ocular Surface Disease Index (OSDI) results were analyzed.
The mean MG loss values were 29.9 ± 11.9 and 20.8 ± 11.0 in the PCOS and control groups, respectively (p < 0.001). MG loss (meiboscale ≥ 1) was determined in 64 (96.9%) eyes in the PCOS group and in 36 (85.7%) eyes in the control group. There was no significant difference between the groups in respect of NITBUT, OSDI, Km, CCT, TCT, ACD, ACV, ICA and CV values (p > 0.05, for all).
MG loss is a physiological process which is distinct in PCOS patients, but does not cause tear film alterations. Further studies are needed to show the contributing factors of MGD in PCOS patients.
比较多囊卵巢综合征（PCOS）患者与健康女性的睑板腺（MG）、非侵入性泪膜破裂时间（NITBUT）和角膜及眼前段测量值。
该研究纳入了 66 名多囊卵巢综合征（PCOS）患者和 42 名年龄在 18-35 岁的健康志愿者。分析了首次和平均 NITBUT、MG 丢失量、平均角膜曲率（Km）、中央（CCT）和最薄（TCT）角膜厚度、前房深度（ACD）、前房容积（ACV）、虹膜角膜角（ICA）、角膜容积（CV）和眼表疾病指数（OSDI）结果。
PCOS 组和对照组的平均 MG 丢失值分别为 29.9±11.9 和 20.8±11.0（p<0.001）。MG 丢失（meiboscale≥1）在 PCOS 组的 66 只眼中有 64 只（96.9%），在对照组的 36 只眼中有 36 只（85.7%）。两组间 NITBUT、OSDI、Km、CCT、TCT、ACD、ACV、ICA 和 CV 值无显著差异（p>0.05，均为 P>0.05）。
MG 丢失是 PCOS 患者的一种生理过程，但不会引起泪膜改变。需要进一步的研究来阐明 PCOS 患者 MGD 的致病因素。
