Department of Ophthalmology, Bursa Yuksek Ihtisas Training and Research Hospital, Turkey.
Department of Pediatric Endocrinology and Metabolism Clinic, Bursa Yuksek Ihtisas Training and Research Hospital, Turkey.
Ocul Surf. 2019 Oct;17(4):675-682. doi: 10.1016/j.jtos.2019.09.001. Epub 2019 Sep 6.
To compare the meibomian gland (MG), non-invasive tear film break-up time (NITFBUT), anterior segment measurements between healthy children and children with hypogonadism.
A total of 80 eyes of 40 children with hypogonadism and 86 eyes of 43 age- and sex-matched healthy subjects were included in the study. The mean keratometry (Km), maximum keratometry (Kmax), central (CCT), thinnest (TCT) and apical (ACT) corneal thicknesses, corneal volume (CV), anterior chamber depth (ACD), irido-corneal angle (ICA), first and average non-invasive NITFBUT, MG loss, morphology of MGs, and MG distortion grade, specular endothelial cell density (CD), coefficient of variation (CoV), and percentage of hexagonal cells (HG) were analysed.
The mean CCT and TCT values were approximately 20 μm lower on average in patients with hypogonadism (p < 0.05). MG loss was present 56.1% of the healthy children, the ratio increased to 81.3% in children with hypogonadism (p < 0.001). The morphology and distortion grade did not show any significant differences between groups (p > 0.05). The mean NITFBUT value were similar between groups (p > 0.05). The mean CD value did not show any significant difference between groups, however it decreased in the hormone replacement therapy (HRT) group (p = 0.005).
MG loss is a physiological process that is prominent in the condition of sex steroid deficiency, but does not cause tear film alterations in children. Future studies investigating sex and gender effect on the ocular surface system in an age-based fashion are required to clearly communicate influences in the arenas of ocular surface research.
比较正常儿童和低促性腺激素性性腺功能减退症儿童的睑板腺（MG）、非侵入性泪膜破裂时间（NITFBUT）和眼前节测量值。
共纳入 40 例低促性腺激素性性腺功能减退症儿童的 80 只眼和 43 例年龄和性别匹配的健康儿童的 86 只眼。分析平均角膜曲率（Km）、最大角膜曲率（Kmax）、中央角膜厚度（CCT）、最薄角膜厚度（TCT）和顶点角膜厚度（ACT）、角膜容积（CV）、前房深度（ACD）、房角-巩膜角（ICA）、第一和平均非侵入性 NITFBUT、MG 缺失、MG 形态和 MG 扭曲程度、角膜内皮细胞密度（CD）、变异系数（CoV）和六边形细胞（HG）百分比。
低促性腺激素性性腺功能减退症患者的平均 CCT 和 TCT 值平均低约 20μm（p<0.05）。健康儿童中 56.1%存在 MG 缺失，而低促性腺激素性性腺功能减退症儿童中这一比例增加至 81.3%（p<0.001）。两组间 MG 形态和扭曲程度无显著差异（p>0.05）。两组间平均 NITFBUT 值无显著差异（p>0.05）。两组间 CD 值无显著差异，但激素替代治疗（HRT）组 CD 值下降（p=0.005）。
MG 缺失是一种在性激素缺乏时明显的生理过程，但不会导致儿童泪膜改变。未来需要进行基于年龄的研究，以明确性别和性别对眼表系统的影响，从而在眼表研究领域进行交流。
