Virsik-Peuckert R P, Harder D
Int J Radiat Biol Relat Stud Phys Chem Med. 1986 Jan;49(1):103-8. doi: 10.1080/09553008514552271.
In unstimulated lymphocytes the enhancing effect of ara C on the yield of X-ray-induced dicentric aberrations was maximal if ara C was added immediately or up to 2 h after irradiation. When ara C was added later the enhancing effect decreased and practically vanished by 5 h. In stimulated lymphocytes the ara C effect declined faster and practically vanished by 3 h. If ara C was added for 1 h immediately after irradiation, then the aberration yield observed in G0, early G1 and late G1 cells was similar whereas it increased significantly from G0 to late G1 cells without ara C post-treatment. The results are discussed in relation to the classical model of aberration formation.
在未受刺激的淋巴细胞中，如果在照射后立即或在照射后2小时内添加阿糖胞苷（ara C），其对X射线诱导的双着丝粒畸变产量的增强作用最大。当在更晚的时间添加阿糖胞苷时，增强作用会降低，到5小时时实际上就消失了。在受刺激的淋巴细胞中，阿糖胞苷的作用下降得更快，到3小时时实际上就消失了。如果在照射后立即添加阿糖胞苷1小时，那么在G0期、早期G1期和晚期G1期细胞中观察到的畸变产量相似，而在没有阿糖胞苷处理的情况下，从G0期到晚期G1期细胞，畸变产量会显著增加。结合畸变形成的经典模型对结果进行了讨论。
