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脐带血干细胞移植治疗一例严重进行性核上性麻痹患者：病例报告

Umbilical cord blood stem cells transplantation in a patient with severe progressive supranuclear palsy: a case report.

作者信息

Li Huiping, Yuan Fang, Du Yaming, Pan Tao, Wen Wanxin, Li Shaoxue, Wang Lixin, Lu Aili

机构信息

Department of Neurocritical Care, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, 510120, China.

出版信息

J Med Case Rep. 2021 Nov 29;15(1):574. doi: 10.1186/s13256-021-03139-z.

DOI:10.1186/s13256-021-03139-z
PMID:34844635
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8628425/
Abstract

BACKGROUND

Progressive supranuclear palsy is a neurodegenerative condition that worsens over time. Given the lack of targeted treatments, patients with severe progressive supranuclear palsy have very low life expectancy.

CASE PRESENTATION

We present a case of a 61-year-old Chinese man with severe progressive supranuclear palsy and treated with umbilical cord blood stem cells transplantation. After the umbilical cord blood stem cells therapy, his neurologic symptoms stopped deteriorating, his muscle rigidity was mildly improved, and he remains alive for more than 8 years.

CONCLUSIONS

Umbilical cord blood stem cells transplantation may be an alternative therapy for patients with severe progressive supranuclear palsy.

摘要

背景

进行性核上性麻痹是一种随时间推移而恶化的神经退行性疾病。鉴于缺乏针对性治疗，重度进行性核上性麻痹患者的预期寿命非常低。

病例报告

我们报告一例61岁的中国男性，患有重度进行性核上性麻痹，并接受了脐带血干细胞移植治疗。脐带血干细胞治疗后，他的神经症状停止恶化，肌肉僵硬稍有改善，并且存活了8年多。

结论

脐带血干细胞移植可能是重度进行性核上性麻痹患者的一种替代治疗方法。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4dc6/8628425/3f9e9bea76c4/13256_2021_3139_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4dc6/8628425/d7b182d02c23/13256_2021_3139_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4dc6/8628425/76ee2f58d69f/13256_2021_3139_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4dc6/8628425/3f9e9bea76c4/13256_2021_3139_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4dc6/8628425/d7b182d02c23/13256_2021_3139_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4dc6/8628425/76ee2f58d69f/13256_2021_3139_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4dc6/8628425/3f9e9bea76c4/13256_2021_3139_Fig3_HTML.jpg

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