Joiner M C, Denekamp J
Int J Radiat Biol Relat Stud Phys Chem Med. 1986 Jan;49(1):143-50. doi: 10.1080/09553008514552311.
The response of mouse skin to small X-ray doses (less than or equal to 4.5 Gy) has been studied using gross skin reactions to obtain dose response curves. In order to study such small doses without giving a very prolonged series of fractions, the 'top-up' or partial tolerance design of experiment has been used. Eight or twenty priming fractions of X-rays have been 'topped up' with graded single doses of 3 MeV neutrons to bring the sub-threshold X-ray damage into the measurable range. By this means the effect of the same dose could be studied, when given either 8 or 20 times. The data were analysed to see whether each fraction was equally effective in the long or short fractionation schedules. The effectiveness remained constant, showing no significant loss of the repair capacity as the fractionation schedule proceeded.
利用小鼠皮肤的总体反应来研究其对小剂量X射线（小于或等于4.5 Gy）的反应，以获得剂量反应曲线。为了在不给予非常长时间的分次照射系列的情况下研究如此小的剂量，采用了“补充”或部分耐受性实验设计。用分级单剂量的3 MeV中子对8次或20次X射线预照射分次进行“补充”，以使亚阈值X射线损伤进入可测量范围。通过这种方式，可以研究相同剂量在给予8次或20次时的效果。对数据进行分析，以查看在长分次或短分次方案中每个分次是否同样有效。有效性保持恒定，表明随着分次方案的进行，修复能力没有显著丧失。
