巨细胞动脉炎与 PD-1 抑制相关。
Giant cell arteritis associated with PD-1 inhibition.
机构信息
Rheumatology & Immunology, Ohio State University Wexner Medical Center, Columbus, Ohio, USA.
Rheumatology & Immunology, Ohio State University Wexner Medical Center, Columbus, Ohio, USA
出版信息
BMJ Case Rep. 2021 Nov 29;14(11):e246443. doi: 10.1136/bcr-2021-246443.
A 50-year-old woman was referred to rheumatology for new onset polyarthralgia and headache. She had a history of metastatic lung adenocarcinoma and was started on treatment with the programmed death 1 receptor (PD-1) antagonist pembrolizumab 2 months prior. Examination revealed left temporal artery tenderness and hand synovitis. Investigations revealed enlarged temporal artery on ultrasound imaging. On steroid treatment, she had resolution of symptoms, but due to significant steroid side effects required methotrexate and her PD-1 antagonist therapy was continued in consultation with her oncologist. Her malignant disease has remained stable, and she has improved functional status.
一位 50 岁女性因新发多发性关节痛和头痛被转至风湿病科。她患有转移性肺腺癌，并在 2 个月前开始接受程序性死亡受体 1（PD-1）拮抗剂 pembrolizumab 治疗。检查发现左侧颞动脉触痛和手部滑膜炎。检查发现超声成像显示颞动脉增大。在接受类固醇治疗后，她的症状得到缓解，但由于类固醇的严重副作用，她需要接受甲氨蝶呤治疗，并且在与肿瘤医生协商后继续接受 PD-1 拮抗剂治疗。她的恶性疾病保持稳定，功能状态有所改善。
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