糖尿病性高甘油三酯血症与阿尔茨海默病：是否存在因果关系？
Diabetic hypertriglyceridaemia and Alzheimer's disease: causal or not?
作者信息
Takechi Ryusuke, Lam Virginie, Mamo John C L
机构信息
Curtin Health Innovation Research Institute, Curtin University, Perth, Western Australia, Australia.
出版信息
Curr Opin Endocrinol Diabetes Obes. 2022 Apr 1;29(2):101-105. doi: 10.1097/MED.0000000000000696.
PURPOSE OF REVIEW
To summarize recent findings considering type II diabetes, or metabolic syndrome dyslipidaemia with risk for Alzheimer's disease.
RECENT FINDINGS
Population, genetic, clinical and preclinical studies support the hypothesis of increased risk for Alzheimer's disease in type 2 diabetes mellitus. The mechanisms are unclear. However, recent studies suggest that aberrations in the peripheral metabolism of triglyceride-rich-lipoproteins compromise the brain microvasculature.
SUMMARY
We review the literature of prediabetic metabolic syndrome and type 2 diabetes mellitus as a risk factor for Alzheimer's disease. We focus on a potential association with aberrations in the systemic metabolism of triglyceride-rich-lipoproteins reported over 18 months.
综述目的
总结近期关于2型糖尿病或伴有阿尔茨海默病风险的代谢综合征血脂异常的研究发现。
近期研究发现
人群、遗传、临床和临床前研究支持2型糖尿病患者患阿尔茨海默病风险增加的假说。其机制尚不清楚。然而，近期研究表明，富含甘油三酯脂蛋白的外周代谢异常会损害脑微血管系统。
总结
我们综述了糖尿病前期代谢综合征和2型糖尿病作为阿尔茨海默病危险因素的文献。我们重点关注了过去18个月报道的与富含甘油三酯脂蛋白的全身代谢异常的潜在关联。
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