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Genetic and epigenetic regulation of the NRF2-KEAP1 pathway in human lung cancer.人类肺癌中 NRF2-KEAP1 通路的遗传和表观遗传调控。
Br J Cancer. 2022 May;126(9):1244-1252. doi: 10.1038/s41416-021-01642-0. Epub 2021 Nov 29.
2
Epigenetic versus Genetic Deregulation of the KEAP1/NRF2 Axis in Solid Tumors: Focus on Methylation and Noncoding RNAs.表观遗传与遗传调控在实体瘤中 KEAP1/NRF2 轴的失衡：聚焦甲基化和非编码 RNA。
Oxid Med Cell Longev. 2018 Mar 13;2018:2492063. doi: 10.1155/2018/2492063. eCollection 2018.
3
Epigenetic modifications but not genetic polymorphisms regulate KEAP1 expression in colorectal cancer.表观遗传修饰而非遗传多态性调节结直肠癌中 KEAP1 的表达。
J Cell Biochem. 2019 Aug;120(8):12311-12320. doi: 10.1002/jcb.28495. Epub 2019 Mar 1.
4
Epigenetic regulation of Keap1-Nrf2 signaling.Keap1-Nrf2信号通路的表观遗传调控
Free Radic Biol Med. 2015 Nov;88(Pt B):337-349. doi: 10.1016/j.freeradbiomed.2015.06.013. Epub 2015 Jun 25.
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Mutations in the KEAP1-NFE2L2 Pathway Define a Molecular Subset of Rapidly Progressing Lung Adenocarcinoma.KEAP1-NFE2L2 通路突变定义了快速进展型肺腺癌的一个分子亚型。
J Thorac Oncol. 2019 Nov;14(11):1924-1934. doi: 10.1016/j.jtho.2019.07.003. Epub 2019 Jul 16.
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Stress-sensing mechanisms and the physiological roles of the Keap1-Nrf2 system during cellular stress.细胞应激过程中Keap1-Nrf2系统的应激感应机制及生理作用。
J Biol Chem. 2017 Oct 13;292(41):16817-16824. doi: 10.1074/jbc.R117.800169. Epub 2017 Aug 24.
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Keap1/Nrf2 pathway in kidney cancer: frequent methylation of KEAP1 gene promoter in clear renal cell carcinoma.肾癌中的Keap1/Nrf2信号通路：肾透明细胞癌中KEAP1基因启动子频繁甲基化
Oncotarget. 2017 Feb 14;8(7):11187-11198. doi: 10.18632/oncotarget.14492.
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The vicious circle of UHRF1 down-regulation and KEAP1/NRF2/HO-1 pathway impairment promotes oxidative stress-induced endothelial cell apoptosis in diabetes.UHRF1下调与KEAP1/NRF2/HO-1通路受损的恶性循环促进了糖尿病中氧化应激诱导的内皮细胞凋亡。
Diabet Med. 2023 Apr;40(4):e15026. doi: 10.1111/dme.15026. Epub 2022 Dec 21.
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Clinicopathological, microenvironmental and genetic determinants of molecular subtypes in KEAP1/NRF2-mutant lung cancer.KEAP1/NRF2 突变型肺癌中分子亚型的临床病理、微环境和遗传决定因素。
Int J Cancer. 2019 Feb 15;144(4):788-801. doi: 10.1002/ijc.31975. Epub 2018 Dec 4.
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Therapeutic Targeting of the NRF2 Signaling Pathway in Cancer.癌症中 NRF2 信号通路的治疗靶向。
Molecules. 2021 Mar 5;26(5):1417. doi: 10.3390/molecules26051417.
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Targeting the Keap1/Nrf2 axis in cancer: molecular mechanisms and pharmacological interventions.靶向癌症中的Keap1/Nrf2轴：分子机制与药理干预
Invest New Drugs. 2025 Sep 5. doi: 10.1007/s10637-025-01578-9.
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NRF2 regulates lipid droplet dynamics to prevent lipotoxicity.核因子E2相关因子2（NRF2）调节脂滴动态变化以预防脂毒性。
iScience. 2025 Jun 18;28(7):112925. doi: 10.1016/j.isci.2025.112925. eCollection 2025 Jul 18.
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Hsa_circ_0018909 promotes non-small cell lung cancer by directly regulating hsa-miR-513b-5p.Hsa_circ_0018909通过直接调控hsa-miR-513b-5p促进非小细胞肺癌。
Front Oncol. 2025 Jun 23;15:1542742. doi: 10.3389/fonc.2025.1542742. eCollection 2025.
4
Decoding the NRF2-NOTCH Crosstalk in Lung Cancer-An Update.肺癌中NRF2-NOTCH信号通路交互作用的解析——最新进展
Antioxidants (Basel). 2025 May 29;14(6):657. doi: 10.3390/antiox14060657.
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Molecular Targets of Oxidative Stress: Focus on Nuclear Factor Erythroid 2-Related Factor 2 Function in Leukemia and Other Cancers.氧化应激的分子靶点：聚焦于核因子红细胞2相关因子2在白血病及其他癌症中的功能
Cells. 2025 May 14;14(10):713. doi: 10.3390/cells14100713.
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Targeting epigenetic and post-translational modifications of NRF2: key regulatory factors in disease treatment.靶向NRF2的表观遗传和翻译后修饰：疾病治疗中的关键调控因子
Cell Death Discov. 2025 Apr 21;11(1):189. doi: 10.1038/s41420-025-02491-z.
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Oxidative Stress-Related KEAP1 and NRF2 Genes Contributed to the Risk of Epithelial Ovarian Cancer.氧化应激相关的KEAP1和NRF2基因与上皮性卵巢癌风险相关。
Biochem Genet. 2025 Feb 13. doi: 10.1007/s10528-025-11044-z.
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Proteostasis Decline and Redox Imbalance in Age-Related Diseases: The Therapeutic Potential of NRF2.衰老相关疾病中的蛋白质稳态衰退与氧化还原失衡：NRF2的治疗潜力
Biomolecules. 2025 Jan 13;15(1):113. doi: 10.3390/biom15010113.
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Recent advances in reactive oxygen species (ROS)-responsive drug delivery systems for photodynamic therapy of cancer.用于癌症光动力治疗的活性氧（ROS）响应型药物递送系统的最新进展
Acta Pharm Sin B. 2024 Dec;14(12):5106-5131. doi: 10.1016/j.apsb.2024.10.015. Epub 2024 Nov 2.
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Kelch-like ECH-associated Protein 1/Nuclear Factor Erythroid 2-related Factor 2 Pathway and Its Interplay with Oncogenes in Lung Tumorigenesis.kelch样ECH相关蛋白1/核因子红细胞2相关因子2通路及其在肺癌发生中与癌基因的相互作用
J Cancer Prev. 2024 Dec 30;29(4):89-98. doi: 10.15430/JCP.24.021.
本文引用的文献
1
Targeting NRF2 to treat cancer.靶向 NRF2 治疗癌症。
Semin Cancer Biol. 2021 Nov;76:61-73. doi: 10.1016/j.semcancer.2021.06.003. Epub 2021 Jun 5.
2
The intricacies of NRF2 regulation in cancer.NRF2 调控在癌症中的复杂性。
Semin Cancer Biol. 2021 Nov;76:110-119. doi: 10.1016/j.semcancer.2021.05.016. Epub 2021 May 18.
3
Therapeutic Targeting of the NRF2 Signaling Pathway in Cancer.癌症中 NRF2 信号通路的治疗靶向。
Molecules. 2021 Mar 5;26(5):1417. doi: 10.3390/molecules26051417.
4
Evaluation of the Epigenetic Demethylation of NRF2, a Master Transcription Factor for Antioxidant Enzymes, in Colorectal Cancer.评估NRF2（抗氧化酶的主要转录因子）在结直肠癌中的表观遗传去甲基化情况。
Rep Biochem Mol Biol. 2020 Apr;9(1):33-39. doi: 10.29252/rbmb.9.1.33.
5
Redox toxicology of environmental chemicals causing oxidative stress.环境化学物引起氧化应激的氧化还原毒理学。
Redox Biol. 2020 Jul;34:101475. doi: 10.1016/j.redox.2020.101475. Epub 2020 Apr 18.
6
Integrated data analysis reveals significant associations of mutations with DNA methylation alterations in lung adenocarcinomas.整合数据分析揭示了肺腺癌中突变与 DNA 甲基化改变之间的显著关联。
Aging (Albany NY). 2020 Apr 23;12(8):7183-7206. doi: 10.18632/aging.103068.
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Induction of the Antioxidant Response by the Transcription Factor NRF2 Increases Bioactivation of the Mutagenic Air Pollutant 3-Nitrobenzanthrone in Human Lung Cells.转录因子 NRF2 诱导抗氧化反应增加了诱变空气污染物 3-硝基苯并蒽在人肺细胞中的生物活化。
Chem Res Toxicol. 2019 Dec 16;32(12):2538-2551. doi: 10.1021/acs.chemrestox.9b00399. Epub 2019 Nov 20.
8
MicroRNA-421 confers paclitaxel resistance by binding to the KEAP1 3'UTR and predicts poor survival in non-small cell lung cancer.miRNA-421 通过与 KEAP1 3'UTR 结合赋予紫杉醇耐药性，并预测非小细胞肺癌患者的生存不良。
Cell Death Dis. 2019 Oct 28;10(11):821. doi: 10.1038/s41419-019-2031-1.
9
Distinct initiating events underpin the immune and metabolic heterogeneity of KRAS-mutant lung adenocarcinoma.KRAS 突变型肺腺癌的免疫和代谢异质性由不同的起始事件驱动。
Nat Commun. 2019 Sep 13;10(1):4190. doi: 10.1038/s41467-019-12164-y.
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ROS Generation and Antioxidant Defense Systems in Normal and Malignant Cells.正常细胞和恶性细胞中的 ROS 生成和抗氧化防御系统。
Oxid Med Cell Longev. 2019 Aug 5;2019:6175804. doi: 10.1155/2019/6175804. eCollection 2019.
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