Theodore W H, DiChiro G, Margolin R, Fishbein D, Porter R J, Brooks R A
Neurology. 1986 Jan;36(1):60-4. doi: 10.1212/wnl.36.1.60.
We studied the effect of barbiturates on local cerebral glucose metabolism by performing positron emission scans before and after withdrawal of phenobarbital or primidone. The postwithdrawal scan showed a significant increase (mean, 37%) in seven of eight cortical regions tested. Patients who had serial scans without a drug change showed a nonsignificant tendency for metabolic rates to go down on the second scan (mean decrease, 7%). Addition or deletion of a single drug other than barbiturate did not change metabolic rates on repeat scans. The depression in cerebral glucose metabolic rate due to phenobarbital, if confirmed, may have bearing on the adverse neuropsychological effects of the drug.
我们通过在停用苯巴比妥或扑米酮前后进行正电子发射扫描，研究了巴比妥类药物对局部脑葡萄糖代谢的影响。停药后的扫描显示，在测试的八个皮质区域中的七个区域有显著增加（平均增加37%）。在没有药物变化的情况下进行系列扫描的患者，第二次扫描时代谢率有下降的非显著趋势（平均下降7%）。除巴比妥类药物外，添加或停用单一药物不会改变重复扫描时的代谢率。如果得到证实，苯巴比妥引起的脑葡萄糖代谢率降低可能与该药物的不良神经心理效应有关。
