苯妥英对人体脑葡萄糖代谢的影响。

Effect of phenytoin on human cerebral glucose metabolism.

作者信息

Theodore W H, Bairamian D, Newmark M E, DiChiro G, Porter R J, Larson S, Fishbein D

出版信息

J Cereb Blood Flow Metab. 1986 Jun;6(3):315-20. doi: 10.1038/jcbfm.1986.54.

DOI:10.1038/jcbfm.1986.54

Abstract

We used serial positron emission tomography scans with [18F]2-deoxyglucose to study the effect of phenytoin on human cerebral glucose metabolism in 10 patients with seizure disorders. Local CMRglu for each patient was measured in 10 regions of interest. EEGs were performed during each procedure to match scans for state of consciousness and exclude data from scans with ictal activity. Serial scans without a drug change were performed in six control patients. Metabolic rates were significantly lower in two cortical regions while patients were taking phenytoin. No significant changes on repeat scan were seen in the control population. Measured across all regions of interest, metabolic rates were 13% higher when patients were off phenytoin (p less than 0.02).

摘要

我们使用[18F]2-脱氧葡萄糖进行系列正电子发射断层扫描，以研究苯妥英对10例癫痫患者大脑葡萄糖代谢的影响。在10个感兴趣区域测量了每位患者的局部脑葡萄糖代谢率（CMRglu）。在每个检查过程中进行脑电图检查，以匹配扫描时的意识状态，并排除有发作期活动扫描的数据。对6名对照患者进行了不改变药物的系列扫描。患者服用苯妥英时，两个皮质区域的代谢率显著降低。对照组重复扫描未见明显变化。在所有感兴趣区域进行测量，患者停用苯妥英时代谢率高出13%（p<0.02）。