Department of Pharmacology, Faculty of Pharmacy, Delta University for Science and Technology Gamasa, Talkha, Egypt.
Department of Pharmacology and Toxicology, Faculty of Pharmacy, Suez Canal University, Ismailia, Egypt.
Environ Sci Pollut Res Int. 2022 Apr;29(17):25723-25732. doi: 10.1007/s11356-021-17831-6. Epub 2021 Nov 30.
Diabetes is a clinical condition that is associated with insulin deficiency and hyperglycemia. Cardiomyopathy, retinopathy, neuropathy, and nephropathy are well known complications of the elevated blood glucose. Diabetic cardiomyopathy is a clinical disorder that is associated with systolic and diastolic dysfunction along with cardiac fibrosis, inflammation, and elevated oxidative stress. In this study, diabetes was induced by intraperitoneal injection of streptozotocin (STZ) 50 mg/kg. We determined the plasma levels of cardiac troponin-T (cTnT) and creatinine kinase MB (CK-MB) by ELISA. Diabetic rats showed abnormal cardiac architecture and increased collagen production. Significant elevation in ST-segment, prolonged QRS, and QT-intervals and increased ventricular rate were detected. Additionally, diabetic rats showed a prolongation in P wave duration and atrial tachyarrhythmia was observed. Plasma levels of cTnT and CK-MB were elevated. In conclusion, these electrocardiographic changes (elevated ST-segment, prolonged QT interval, and QRS complex, and increased heart rate) along with histopathological changes and increased collagen formation could be markers for the development of diabetic cardiomyopathy in rats.
糖尿病是一种与胰岛素缺乏和高血糖有关的临床病症。心肌病变、视网膜病变、神经病变和肾病是已知的血糖升高的并发症。糖尿病性心肌病是一种与收缩和舒张功能障碍以及心脏纤维化、炎症和氧化应激升高相关的临床疾病。在这项研究中，糖尿病是通过腹腔注射链脲佐菌素（STZ）50mg/kg 诱导的。我们通过 ELISA 测定了血浆中心肌钙蛋白-T（cTnT）和肌酸激酶 MB（CK-MB）的水平。糖尿病大鼠表现出异常的心脏结构和胶原产生增加。检测到 ST 段抬高、QRS 延长和 QT 间隔延长以及心室率增加。此外，糖尿病大鼠还表现出 P 波持续时间延长和房性心动过速。cTnT 和 CK-MB 的血浆水平升高。总之，这些心电图变化（ST 段抬高、QT 间期延长和 QRS 复合体延长以及心率增加）以及组织病理学变化和胶原形成增加可能是大鼠糖尿病性心肌病发展的标志物。
