Department of Dermatology, Inselspital, Bern University Hospital, University of Bern, Switzerland.
Dermatol Ther. 2022 Feb;35(2):e15236. doi: 10.1111/dth.15236. Epub 2021 Dec 6.
Wound products that reliably support healing of chronic leg ulcers remain a huge unmet need in clinical practice. Due to the lack of standardized comparable protocols and different systems for platelet-rich plasma (PRP) preparation, there is limited data on healing rates in chronic venous ulcers. In our case series with a total of seven chronic leg ulcers in four patients, we investigated the healing rates based on standardized digital photographs of chronic venous ulcers after application of topical PRP using a digital imaging software. In 5 out of 7 ulcers, the PRP-treated wound half showed faster healing as compared the control half of the wound. In this case series, PRP-treated sides of chronic venous leg ulcers showed a tendency for accelerated healing as compared to nontreated collateral wound side. Our data support the evaluation of topical PRP treatment in the management of chronic venous leg ulcers.
在临床实践中，可靠地支持慢性腿部溃疡愈合的伤口产品仍然是一个巨大的未满足的需求。由于缺乏标准化的可比方案和不同的富血小板血浆 (PRP) 制备系统，因此关于慢性静脉溃疡的愈合率的数据有限。在我们的病例系列中，共有四名患者的七种慢性腿部溃疡，我们使用数字成像软件对慢性静脉溃疡应用局部 PRP 后的标准化数字照片进行了愈合率调查。在 7 个溃疡中有 5 个，PRP 治疗的伤口半侧比对照的伤口半侧愈合更快。在本病例系列中，与未经治疗的侧支伤口相比，慢性静脉性腿部溃疡的 PRP 治疗侧显示出加速愈合的趋势。我们的数据支持在慢性静脉性腿部溃疡的管理中评估局部 PRP 治疗。
