高 1 年死亡率风险的血液透析患者的血清转甲状腺素蛋白水平范围：一项回顾性队列研究。
Range of serum transthyretin levels in hemodialysis patients at a high risk of 1-year mortality: A retrospective cohort study.
机构信息
Kenwakai Hospital, Iida, Japan.
Department of Innovative Medicine, Osaka Medical College, Takatsuki, Japan.
出版信息
Ther Apher Dial. 2022 Aug;26(4):743-748. doi: 10.1111/1744-9987.13768. Epub 2021 Dec 8.
INTRODUCTION
Transthyretin (TTR) is a sensitive marker of nutritional status and independent risk factor for mortality in hemodialysis patients. However, its range associated with prognosis in Japanese hemodialysis patients is unknown.
METHODS
Maintenance hemodialysis Patients (n = 664) were enrolled, and their TTR levels were measured to assess 1-year mortality. Patients were assigned to four groups based on TTR levels: <20, 20 to <30 (control), 30 to <40, and ≥40 mg/dl. One-year mortality at each TTR range was analyzed using a Cox proportional hazards model after adjustment for prognostic factors.
RESULTS
Seventy-seven (11.6%) deaths were recorded during follow-up. The hazard ratio (HR) of TTR <20 mg/dl was significantly higher compared with the control group in terms of all-causes (HR: 3.14) and non-cardiovascular mortality (HR: 6.986).
CONCLUSION
TTR levels were independent and sensitive predictors of mortality in hemodialysis patients. TTR <20 mg/dl is a risk factor for 1-year mortality in Japanese hemodialysis patients.
简介
转甲状腺素（TTR）是血液透析患者营养状况的敏感标志物，也是独立的死亡风险因素。然而，其与日本血液透析患者预后相关的范围尚不清楚。
方法
纳入 664 名维持性血液透析患者，测量其 TTR 水平以评估 1 年死亡率。根据 TTR 水平将患者分为四组：<20、20-<30（对照组）、30-<40 和 ≥40mg/dl。使用 Cox 比例风险模型调整预后因素后，分析每个 TTR 范围内的 1 年死亡率。
结果
在随访期间记录了 77 例（11.6%）死亡。与对照组相比，TTR<20mg/dl 的全因死亡（HR：3.14）和非心血管死亡（HR：6.986）风险比显著更高。
结论
TTR 水平是血液透析患者死亡的独立和敏感预测因子。TTR<20mg/dl 是日本血液透析患者 1 年死亡率的危险因素。
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