Kenwakai Hospital, Iida, Japan.
Department of Innovative Medicine, Osaka Medical College, Takatsuki, Japan.
Ther Apher Dial. 2022 Aug;26(4):743-748. doi: 10.1111/1744-9987.13768. Epub 2021 Dec 8.
Transthyretin (TTR) is a sensitive marker of nutritional status and independent risk factor for mortality in hemodialysis patients. However, its range associated with prognosis in Japanese hemodialysis patients is unknown.
Maintenance hemodialysis Patients (n = 664) were enrolled, and their TTR levels were measured to assess 1-year mortality. Patients were assigned to four groups based on TTR levels: <20, 20 to <30 (control), 30 to <40, and ≥40 mg/dl. One-year mortality at each TTR range was analyzed using a Cox proportional hazards model after adjustment for prognostic factors.
Seventy-seven (11.6%) deaths were recorded during follow-up. The hazard ratio (HR) of TTR <20 mg/dl was significantly higher compared with the control group in terms of all-causes (HR: 3.14) and non-cardiovascular mortality (HR: 6.986).
TTR levels were independent and sensitive predictors of mortality in hemodialysis patients. TTR <20 mg/dl is a risk factor for 1-year mortality in Japanese hemodialysis patients.
转甲状腺素（TTR）是血液透析患者营养状况的敏感标志物，也是独立的死亡风险因素。然而，其与日本血液透析患者预后相关的范围尚不清楚。
纳入 664 名维持性血液透析患者，测量其 TTR 水平以评估 1 年死亡率。根据 TTR 水平将患者分为四组：<20、20-<30（对照组）、30-<40 和 ≥40mg/dl。使用 Cox 比例风险模型调整预后因素后，分析每个 TTR 范围内的 1 年死亡率。
在随访期间记录了 77 例（11.6%）死亡。与对照组相比，TTR<20mg/dl 的全因死亡（HR：3.14）和非心血管死亡（HR：6.986）风险比显著更高。
TTR 水平是血液透析患者死亡的独立和敏感预测因子。TTR<20mg/dl 是日本血液透析患者 1 年死亡率的危险因素。
