Fujian Key Laboratory of Drug Target Discovery and Structural and Functional Research, School of Pharmacy, Fujian Medical University, Fuzhou 350004, China.
Marine Chemistry Lab, Marine Environment Division, National Institute of Oceanography and Fisheries (NIOF), Egypt.
Analyst. 2021 Dec 20;147(1):101-108. doi: 10.1039/d1an01895g.
Heavy metal ions (HMIs), including Cu, Ag, Cd, Hg, and Pb from the environment pose a threat to human beings and can cause a series of life-threatening diseases. Therefore, colorimetric sensors with convenience and flexibility for HMI discrimination are still required. To provide a solution, a peroxidase-like activity-based colorimetric sensor array of citrate-capped noble metal nanozymes (osmium, platinum, and gold) has been fabricated. Some studies reported that some HMIs could interact with the noble metal nanozymes leading to a change in their peroxidase-like activity. This phenomenon was confirmed in our work. Based on this principle, different concentrations of HMIs (Cu, Ag, Cd, Hg, and Pb) were discriminated. Moreover, their practical application has been tested by discriminating HMIs in tap water and SiYu lake water. What is more, as an example of the validity of our method to quantify HMIs at nanomolar concentrations, the LOD of Hg was presented. To sum up, our study not only demonstrates the differentiation ability of this nanozyme sensor array but also gives hints for using nanozyme sensor arrays for further applications.
重金属离子（HMIs），包括环境中的 Cu、Ag、Cd、Hg 和 Pb，对人类构成威胁，并可能导致一系列危及生命的疾病。因此，仍然需要具有便利性和灵活性的用于 HMI 鉴别 的比色传感器。为了解决这个问题，已经制备了基于具有过氧化物酶样活性的纳米酶（钌、铂和金）的柠檬酸盐封端的贵金属纳米酶的过氧化物酶样活性比色传感器阵列。一些研究报告称，一些 HMIs 可以与贵金属纳米酶相互作用，导致其过氧化物酶样活性发生变化。在我们的工作中证实了这一现象。基于这一原理，对不同浓度的 HMIs（Cu、Ag、Cd、Hg 和 Pb）进行了区分。此外，还通过区分自来水中和四玉湖水中的 HMIs 测试了其实际应用。更重要的是，作为我们以纳摩尔浓度定量 HMIs 的方法有效性的一个例子，提出了 Hg 的 LOD。总之，我们的研究不仅证明了这种纳米酶传感器阵列的区分能力，而且为进一步应用纳米酶传感器阵列提供了启示。
