Neurology Department, Democritus University of Thrace, Alexandroupolis, Greece.
Laboratory of Clinical Neurophysiology, Democritus University of Thrace, Alexandroupolis, Greece.
Neurol Sci. 2022 Feb;43(2):873-888. doi: 10.1007/s10072-021-05791-1. Epub 2021 Nov 30.
Stroke represents a major cause of functional disability with increasing prevalence. Thus, it is imperative that stroke prognosis be both timely and valid. Up to today, several biomarkers have been investigated in an attempt to forecast stroke survivors' potential for motor recovery, transcranial magnetic stimulation (TMS) being among them.
A literature research of two databases (MEDLINE and Scopus) was conducted in order to trace all relevant studies published between 1990 and 2021 that focused on the potential utility of TMS implementation on stroke prognosis. Only full-text articles published in the English language were included.
Thirty-nine articles have been traced and included in this review.
Motor evoked potentials (MEPs) recording is indicative of a favorable prognosis concerning the motor recovery of upper and lower extremities' weakness, swallowing and speech difficulties, and the patient's general functional outcome. On the contrary, MEP absence is usually associated with poor prognosis. Relative correlations have also been made among other TMS variants (motor threshold, MEP amplitude, central motor conduction time) and the expected recovery rate. Overall, TMS represents a non-invasive, fast, safe, and reproducible prognostic tool poststroke that could resolve prognostic uncertainties in cases of stroke.
中风是导致功能残疾的主要原因，其发病率呈上升趋势。因此，及时、有效地预测中风患者的预后至关重要。迄今为止，已经有许多生物标志物被研究用于预测中风幸存者的运动恢复潜力，其中包括经颅磁刺激（TMS）。
对两个数据库（MEDLINE 和 Scopus）进行了文献检索，以追踪所有在 1990 年至 2021 年期间发表的、专注于 TMS 在中风预后方面的潜在应用的相关研究。仅纳入发表在英文期刊上的全文文章。
共追踪到 39 篇文章，并纳入本综述。
运动诱发电位（MEPs）记录表明，上肢和下肢无力、吞咽和言语困难以及患者的总体功能结局的运动恢复具有良好的预后。相反，MEP 缺失通常与预后不良相关。TMS 的其他变体（运动阈值、MEP 幅度、中枢运动传导时间）也与预期的恢复率之间存在一定的相关性。总的来说，TMS 是一种非侵入性、快速、安全且可重复的中风后预后评估工具，可以解决中风患者预后的不确定性。
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