Upreti R K, Singh K P, Saxena A K, Shanker R
Environ Res. 1986 Feb;39(1):188-98. doi: 10.1016/s0013-9351(86)80021-4.
Preliminary studies related to immunotoxicologic effects of 2,5-hexanedione, the final major metabolite of n-hexane/MnBk, were carried out in rats following single or repeated exposures. Female albino rats were given either single or seven consecutive oral doses of 0.1, 0.2, or 0.5 X LD50 of 2,5-hexanedione, and a time-related kinetic study was performed using hematology, histology, cellularity, and organ weight/body weight as major parameters. Following single exposure of 2,5-hexanedione to rats, a dose-dependent thymic atrophy was evident at the end of 7 days. The atrophy was reversible when the animals were given 7 days nonexposure rest. In contrast, there was no thymic atrophy when the animals were exposed for 7 consecutive days. Significant decline in the cellular populations of various lymphoid organs was also observed in rats exposed either to single or repeated doses of 2,5-hexanedione. Results obtained in the present study indicate that 2,5-hexanedione, a known potent neurotoxic substance, adversely affects the lymphoid organs of the immune system in rats.
正己烷/甲基正丁基酮的最终主要代谢产物2,5 -己二酮免疫毒理学效应的相关初步研究在大鼠单次或重复暴露后进行。给雌性白化大鼠单次或连续7天口服0.1、0.2或0.5倍2,5 -己二酮半数致死剂量（LD50），并以血液学、组织学、细胞计数以及器官重量/体重作为主要参数进行了一项与时间相关的动力学研究。大鼠单次暴露于2,5 -己二酮后，7天结束时出现明显的剂量依赖性胸腺萎缩。当动物给予7天无暴露休息时，这种萎缩是可逆的。相反，动物连续暴露7天时未出现胸腺萎缩。在单次或重复给予2,5 -己二酮剂量的大鼠中，还观察到各种淋巴器官细胞数量显著下降。本研究获得的结果表明，已知的强效神经毒性物质2,5 -己二酮对大鼠免疫系统的淋巴器官产生不利影响。
