Venkateswaran K S, Neeraja V, Sugendran K, Gopalan N, Vijayaraghavan R, Pant S C, Prakash A O, Malhotra R C
Defence Research and Development Establishment, Gwalior, India.
Hum Exp Toxicol. 1994 Apr;13(4):247-51. doi: 10.1177/096032719401300404.
The effects of a single dermal application of sublethal doses [15.5, 7.75 and 3.88 mg kg-1] of bis(2-chloroethyl)sulphide [sulphur mustard, SM] on body weight, organ/body weight ratio, haematology, histology and cellularity of spleen and thymus were studied after 7 days, in Balb/c mice. A progressive fall in body weight was noticed from the fifth day onwards after SM treatment. A dose-dependent decrease in the relative weights of spleen, liver and peripheral lymph nodes, and an increase in adrenal weight were also seen. An increase in red blood cell count, packed cell volume and haemoglobin concentration following SM intoxication were also dose dependent. These changes, together with a significant reduction in the cellularity of the spleen and thymus and degenerative histological changes, show that a single sublethal dermal dose of SM can cause considerable dose dependent systemic effects in Balb/c mice.
研究了在Balb/c小鼠中，单次经皮给予亚致死剂量[15.5、7.75和3.88毫克/千克]的双(2-氯乙基)硫化物[硫芥，SM]7天后，对体重、器官/体重比、血液学、脾脏和胸腺的组织学及细胞数量的影响。SM处理后从第五天起体重逐渐下降。还观察到脾脏、肝脏和外周淋巴结相对重量呈剂量依赖性降低，肾上腺重量增加。SM中毒后红细胞计数、红细胞压积和血红蛋白浓度增加也呈剂量依赖性。这些变化，连同脾脏和胸腺细胞数量的显著减少以及退行性组织学变化，表明单次亚致死经皮剂量的SM可在Balb/c小鼠中引起相当大的剂量依赖性全身效应。
