分选连接蛋白：在血压调节中的作用
Sorting nexins: role in the regulation of blood pressure.
作者信息
Huang Juan, Tiu Andrew C, Jose Pedro A, Yang Jian
机构信息
Department of Clinical Nutrition, The Third Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Department of Medicine, Einstein Medical Center Philadelphia, PA, USA.
出版信息
FEBS J. 2023 Feb;290(3):600-619. doi: 10.1111/febs.16305. Epub 2021 Dec 26.
Sorting nexins (SNXs) are a family of proteins that regulate cellular cargo sorting and trafficking, maintain intracellular protein homeostasis, and participate in intracellular signaling. SNXs are also important in the regulation of blood pressure via several mechanisms. Aberrant expression and dysfunction of SNXs participate in the dysregulation of blood pressure. Genetic studies show a correlation between SNX gene variants and the response to antihypertensive drugs. In this review, we summarize the progress in SNX-mediated regulation of blood pressure, discuss the potential role of SNXs in the pathophysiology and treatment of hypertension, and propose novel strategies for the medical therapy of hypertension.
分选连接蛋白（SNXs）是一类蛋白质，可调节细胞货物分选和运输，维持细胞内蛋白质稳态，并参与细胞内信号传导。SNXs还通过多种机制在血压调节中发挥重要作用。SNXs的异常表达和功能障碍参与了血压的失调。遗传学研究表明SNX基因变异与抗高血压药物的反应之间存在关联。在本综述中，我们总结了SNX介导的血压调节方面的进展，讨论了SNXs在高血压病理生理学和治疗中的潜在作用，并提出了高血压药物治疗的新策略。
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