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高压氧治疗促进兔肩袖撕裂模型中腱骨界面愈合。

Hyperbaric oxygen treatment promotes tendon-bone interface healing in a rabbit model of rotator cuff tears.

机构信息

Department of Orthopedics, Central Hospital Affiliated to Shenyang Medical College, Shenyang, Liaoning Province, China.

Department of Rehabilitation, Central Hospital Affiliated to Shenyang Medical College, Shenyang, Liaoning Province, China.

出版信息

Med Gas Res. 2025 Mar 1;15(1):164-170. doi: 10.4103/mgr.MEDGASRES-D-24-00034. Epub 2024 Aug 31.

DOI:10.4103/mgr.MEDGASRES-D-24-00034
PMID:39217428
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11515062/
Abstract

Due to the high-intensity pressure that the shoulder cuff endures, it is prone to traumas and tears. The main critical function of the shoulder cuff muscles is to effectively facilitate shoulder movement and securely maintain the humeral head in the precise center of the joint cavity to prevent superior migration during abduction processes. Shoulder cuff injuries typically involve the muscle-tendon-bone interface, but existing repair techniques do not always guarantee complete and secure healing, leading to retears. Hyperbaric oxygen therapy, as an auxiliary treatment, can significantly promote the muscle-tendon-bone healing process. To explore the impact of hyperbaric oxygen therapy on the bone-tendon interface healing process in a rabbit model specifically designed for shoulder cuff tears, an experiment was conducted on New Zealand white rabbits by performing a full-thickness tear of the supraspinatus tendon in the left shoulder, followed by 2 hours per day of 100% oxygen treatment at 2 absolute atmospheres for 5 days. The results indicate that hyperbaric oxygen therapy significantly enhances vascularization at the interface between the shoulder cuff and tendon-bone, promotes collagen fiber regeneration in the tendon, improves the tensile strength of the tendon-bone complex, and does not have a significant effect on biomechanical stability. This suggests that hyperbaric oxygen therapy has a significant positive impact on the histological and biomechanical healing of shoulder cuff tears in rabbits, expediting the healing process of the tendon-bone interface.

摘要

由于肩袖末端承受的高强度压力,它容易受到创伤和撕裂。肩袖肌肉的主要关键功能是有效地促进肩部运动,并将肱骨头安全地保持在关节腔内的精确中心位置,以防止在外展过程中向上迁移。肩袖损伤通常涉及肌肉-肌腱-骨界面,但现有的修复技术并不总是能保证完全和安全的愈合,导致再撕裂。高压氧治疗作为一种辅助治疗,可以显著促进肌肉-肌腱-骨的愈合过程。为了探讨高压氧治疗对兔模型肩袖撕裂特定设计的骨-腱界面愈合过程的影响,通过对新西兰白兔进行实验,在左侧肩部进行冈上肌腱全层撕裂,然后每天 2 小时在 2 个绝对大气压下接受 100%的氧气治疗,持续 5 天。结果表明,高压氧治疗显著增强了肩袖和肌腱-骨界面的血管生成,促进了肌腱中胶原纤维的再生,提高了肌腱-骨复合体的拉伸强度,对生物力学稳定性没有显著影响。这表明高压氧治疗对兔肩袖撕裂的组织学和生物力学愈合有显著的积极影响,加速了肌腱-骨界面的愈合过程。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d71c/11515062/f6add13ab4ac/MGR-15-164-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d71c/11515062/447bc088c4bd/MGR-15-164-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d71c/11515062/50bb34109d70/MGR-15-164-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d71c/11515062/946c6488d73f/MGR-15-164-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d71c/11515062/f6add13ab4ac/MGR-15-164-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d71c/11515062/447bc088c4bd/MGR-15-164-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d71c/11515062/50bb34109d70/MGR-15-164-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d71c/11515062/946c6488d73f/MGR-15-164-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d71c/11515062/f6add13ab4ac/MGR-15-164-g004.jpg

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本文引用的文献

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2
Hyperbaric oxygen therapy enhances graft healing and mechanical properties after anterior cruciate ligament reconstruction: An experimental study in rabbits.高压氧治疗增强前交叉韧带重建后移植物的愈合和力学性能:兔的实验研究。
J Orthop Res. 2024 Jun;42(6):1210-1222. doi: 10.1002/jor.25787. Epub 2024 Jan 15.
3
Hypothesis: Drainage of the peripheral tissue edema by the hyperbaric oxygen therapy because of hyperoxygenation that constricts arterioles and alters the downstream capillary fluid traffic in affected tissues.
假设:高压氧疗法通过高氧作用排出外周组织水肿,高氧作用会使小动脉收缩并改变受影响组织中毛细血管下游的液体流动。
Bioessays. 2023 Jun;45(6):e2300023. doi: 10.1002/bies.202300023. Epub 2023 Apr 12.
4
Clinical utility of ozone therapy and hyperbaric oxygen therapy in degenerative disc disease.臭氧治疗和高压氧治疗在退行性椎间盘疾病中的临床应用。
Med Gas Res. 2023 Jan-Mar;13(1):1-6. doi: 10.4103/2045-9912.351890.
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Advances in Stem Cell Therapies for Rotator Cuff Injuries.肩袖损伤的干细胞治疗进展
Front Bioeng Biotechnol. 2022 May 25;10:866195. doi: 10.3389/fbioe.2022.866195. eCollection 2022.
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The Effect of Hyperbaric Oxygen Therapy on Markers of Oxidative Stress and the Immune Response in Healthy Volunteers.高压氧疗法对健康志愿者氧化应激标志物和免疫反应的影响。
Front Physiol. 2022 Jan 31;13:826163. doi: 10.3389/fphys.2022.826163. eCollection 2022.
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Hyperbaric Oxygen Treatment: Effects on Mitochondrial Function and Oxidative Stress.高压氧治疗:对线粒体功能和氧化应激的影响。
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Undersea Hyperb Med. 2021 Fourth Quarter;48(4):425-430.
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BMC Musculoskelet Disord. 2021 Aug 31;22(1):749. doi: 10.1186/s12891-021-04634-6.
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Sustained oxygenation accelerates diabetic wound healing by promoting epithelialization and angiogenesis and decreasing inflammation.持续的氧合作用通过促进上皮化和血管生成以及减少炎症来加速糖尿病伤口愈合。
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