Research Unit of Oral Health Sciences, Faculty of Medicine, University of Oulu, Oulu, Finland.
Computational Medicine, Faculty of Medicine, University of Oulu, Oulu, Finland.
BMC Oral Health. 2021 Nov 30;21(1):611. doi: 10.1186/s12903-021-01964-8.
A genome-wide association study is an analytical approach that investigates whether genetic variants across the whole genome contribute to disease progression. The aim of this study was to investigate genome-wide associations of periodontal condition measured as deepened periodontal pockets (≥ 4 mm) in Finnish adults.
This study was based on the data of the national Health 2000 Survey (BRIF8901) in Finland and the Northern Finland Birth Cohort 1966 Study totalling 3,245 individuals. The genotype data were analyzed using the SNPTEST v.2.4.1. The number of teeth with deepened periodontal pockets (≥ 4 mm deep) was employed as a continuous response variable in additive regression analyses performed separately for the two studies and the results were combined in a meta-analysis applying a fixed effects model.
Genome-wide significant associations with the number of teeth with ≥ 4 mm deep pockets were not found at the p-level of < 5 × 10, while in total 17 loci reached the p-level of 5 × 10. Of the top hits, SNP rs4444613 in chromosome 20 showed the strongest association (p = 1.35 × 10).
No statistically significant genome-wide associations with deepened periodontal pockets were found in this study.
全基因组关联研究是一种分析方法，用于研究整个基因组中的遗传变异是否与疾病进展有关。本研究旨在探讨芬兰成年人牙周状况（深牙周袋≥4mm）的全基因组关联。
本研究基于芬兰全国健康 2000 调查（BRIF8901）和芬兰北部出生队列 1966 研究的数据，共纳入了 3245 名个体。使用 SNPTEST v.2.4.1 分析基因型数据。在分别对这两项研究进行的加性回归分析中，将深牙周袋（≥4mm 深）的牙齿数量用作连续反应变量，并应用固定效应模型进行荟萃分析以合并结果。
在 p<0.05 的水平上，没有发现与深牙周袋数量相关的全基因组显著关联，但总共 17 个位点达到了 5×10 的 p 值水平。在最高命中的位点中，20 号染色体上的 SNP rs4444613 显示出最强的关联（p=1.35×10）。
本研究未发现深牙周袋与全基因组显著关联。
