Jeon Ki-Hyun, Kim Hack-Lyoung, Lim Woo-Hyun, Seo Jae-Bin, Kim Sang-Hyun, Zo Joo-Hee, Kim Myung-A
Cardiovascular center, Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Republic of Korea.
Division of Cardiology, Department of Internal Medicine, SMG-SNU Boramae Medical Center, Seoul, Republic of Korea.
Clin Hypertens. 2021 Dec 1;27(1):23. doi: 10.1186/s40885-021-00179-x.
It is not well-known which components of central blood pressure (CBP) are more influential to target organ damage (TOD). This study aimed to determine the relationship between CBP measurements and various types of TOD in high-risk patients.
A total of 148 patients who had documented atherosclerotic cardiovascular disease or its multiple risk factors were prospectively enrolled. CBP was measured by using applanation tonometry of the radial artery. The following nine TOD parameters were evaluated: left ventricular mass index, relative wall thickness, septal e' velocity, septal E/e', brachial-ankle pulse wave velocity, ankle-brachial index, estimated glomerular filtration rate, urine protein and obstructive coronary artery disease.
The mean age of the study population was 67.1 ± 9.0 years and 108 (73 %) were male. Among four CBP measurements (systolic, diastolic, mean, and pulse pressures), central pulse pressure (CPP) was associated with the largest number of TOD parameters. As CPP increased, the number of TOD increased (P = 0.010), but this association was not observed in other CBP measurements (P > 0.05 for each).
CPP had a stronger correlation with TOD than other CBP measurements. Non-invasive CPP could be a useful indicator for predicting TOD in patients at high coronary risk.
尚不清楚中心血压（CBP）的哪些组成部分对靶器官损害（TOD）的影响更大。本研究旨在确定高危患者中CBP测量值与各种类型TOD之间的关系。
前瞻性纳入了148例有动脉粥样硬化性心血管疾病或其多种危险因素记录的患者。通过使用桡动脉压平式眼压测量法测量CBP。评估了以下九个TOD参数：左心室质量指数、相对壁厚、室间隔e'速度、室间隔E/e'、臂踝脉搏波速度、踝臂指数、估计肾小球滤过率、尿蛋白和阻塞性冠状动脉疾病。
研究人群的平均年龄为67.1±9.0岁，男性108例（73%）。在四种CBP测量值（收缩压、舒张压、平均压和脉压）中，中心脉压（CPP）与最多的TOD参数相关。随着CPP升高，TOD的数量增加（P = 0.010），但在其他CBP测量值中未观察到这种关联（每种测量值的P>0.05）。
与其他CBP测量值相比，CPP与TOD的相关性更强。无创性CPP可能是预测高冠状动脉风险患者TOD的有用指标。
