Yamashita Sumiyo, Dohi Yasuaki, Takase Hiroyuki, Sugiura Tomonori, Ohte Nobuyuki
Department of Cardio-Renal Medicine and Hypertension, Nagoya City University Graduate School of Medical Sciences , Nagoya , Japan.
Blood Press. 2014 Dec;23(6):356-62. doi: 10.3109/08037051.2014.923250. Epub 2014 Jun 12.
The present study investigated whether brachial and central blood pressures have differential impact on the cardiovascular system in the general population.
The study included 706 subjects (59 ± 10 years) who visited our hospital for a physical check-up. Brachial blood pressure and radial artery pressure waveforms were recorded using an automated device, and the pressure corresponding to the radial late systolic peak (SBP2) was taken as central blood pressure. The concentration of B-type natriuretic peptide and the intima-media thickness of the carotid artery were measured and a cross-sectional analysis was performed.
Brachial blood pressure was 128 ± 18/74 ± 12 (mean blood pressure, 92 ± 13) mmHg and SBP2 was 120 ± 19 mmHg. Although both brachial systolic blood pressure and SBP2 correlated with B-type natriuretic peptide in a univariate analysis, only SBP2 independently correlated with B-type natriuretic peptide after adjustment for possible factors. In contrast, brachial systolic blood pressure, but not SBP2, independently correlated with carotid artery intima-media thickness.
Central blood pressure is more closely associated with left ventricular load than brachial blood pressure, while brachial blood pressure is more strongly associated with vascular damage than central blood pressure.
本研究调查了肱动脉血压和中心血压对一般人群心血管系统的影响是否存在差异。
该研究纳入了706名（59±10岁）到我院进行体检的受试者。使用自动设备记录肱动脉血压和桡动脉压力波形，并将与桡动脉晚期收缩期峰值（SBP2）对应的压力作为中心血压。测量B型利钠肽浓度和颈动脉内膜中层厚度，并进行横断面分析。
肱动脉血压为128±18/74±12（平均血压，92±13）mmHg，SBP2为120±19 mmHg。在单因素分析中，肱动脉收缩压和SBP2均与B型利钠肽相关，但在对可能因素进行校正后，只有SBP2与B型利钠肽独立相关。相反，肱动脉收缩压而非SBP2与颈动脉内膜中层厚度独立相关。
中心血压比肱动脉血压与左心室负荷的相关性更强，而肱动脉血压比中心血压与血管损伤的相关性更强。
