Mehta S R, Sandler R S, Ford R J, Sharma S, Maizel A L
Lymphokine Res. 1986 Winter;5(1):49-57.
The release of a B cell growth factor (BCGF) in medium conditioned by peripheral blood T lymphocytes was shown to be dependent upon accessory cell derived signal(s). T lymphocytes activated with lectin and cultured in the presence of monocytes, or Interleukin 1, provided the in vitro components that were both necessary and sufficient for factor release. B, lymphocytes in the presence of both activated T cells and monocytes, were shown to further augment the amount of factor released by the T cell. The effects of the monocyte and B lymphocyte were, in part, mediated through the DR locus and these effects were consistent with a positive feedback mechanism for the regulation of the availability of BCGF. The data are discussed in terms of differing accessory cell roles for the monocyte and B cell in terms of the mechanisms underlying their augmentative effects on factor release.
外周血T淋巴细胞条件培养液中B细胞生长因子（BCGF）的释放被证明依赖于辅助细胞衍生的信号。用凝集素激活并在单核细胞或白细胞介素1存在下培养的T淋巴细胞，提供了体外因子释放所需且充分的成分。在活化T细胞和单核细胞同时存在的情况下，B淋巴细胞被证明可进一步增加T细胞释放的因子量。单核细胞和B淋巴细胞的作用部分是通过DR基因座介导的，这些作用与BCGF可用性调节的正反馈机制一致。根据单核细胞和B细胞在因子释放增强作用的潜在机制方面不同的辅助细胞作用，对这些数据进行了讨论。
