Andalusian Centre for Molecular Biology and Regenerative Medicine-CABIMER, CSIC-Universidad de Sevilla-Universidad Pablo de Olavide, Av. Américo Vespucio 24, 41092 Seville, Spain.
Andalusian Centre for Molecular Biology and Regenerative Medicine-CABIMER, CSIC-Universidad de Sevilla-Universidad Pablo de Olavide, Av. Américo Vespucio 24, 41092 Seville, Spain.
Semin Cell Dev Biol. 2022 Dec;132:203-212. doi: 10.1016/j.semcdb.2021.11.022. Epub 2021 Nov 27.
In the last decades, the post-translational modification system by covalent attachment of the SUMO polypeptide to proteins has emerged as an essential mechanism controlling virtually all the physiological processes in the eukaryotic cell. This includes vertebrate development. In the nervous system, SUMO plays crucial roles in synapse establishment and it has also been linked to a variety of neurodegenerative diseases. However, to date, the involvement of the modification of specific targets in key aspects of nervous system development, like patterning and differentiation, has remained largely elusive. A number of recent works confirm the participation of target-specific SUMO modification in critical aspects of nervous system development. Here, we review pioneering and new findings demonstrating the essential role SUMO plays in neurogenesis and other facets of neurodevelopment, which will help to precisely understand the variety of mechanisms SUMO utilizes to control most fundamental processes in the cell.
在过去的几十年中，通过 SUMO 多肽共价连接到蛋白质的翻译后修饰系统已成为控制真核细胞中几乎所有生理过程的重要机制。这包括脊椎动物的发育。在神经系统中，SUMO 在突触形成中起着至关重要的作用，它也与多种神经退行性疾病有关。然而，迄今为止，特定靶标的修饰在神经系统发育的关键方面（如模式形成和分化）中的参与在很大程度上仍然难以捉摸。最近的一些研究工作证实了靶标特异性 SUMO 修饰在神经系统发育的关键方面的参与。在这里，我们回顾了开创性的和新的发现，这些发现证明了 SUMO 在神经发生和神经发育的其他方面中发挥着重要作用，这将有助于精确理解 SUMO 利用多种机制来控制细胞中最基本过程的方式。
