Brott T G, Gelfand M J, Williams C C, Spilker J A, Hertzberg V S
Radiology. 1986 Mar;158(3):729-34. doi: 10.1148/radiology.158.3.3484833.
Single photon emission computed tomography (SPECT) was performed in 31 patients with cerebral infarction and 13 who had had transient ischemic attacks, using iodine-123-labeled N,N,N'-trimethyl-N'-(2-hydroxyl-3-methyl-5-iodobenzyl)-1,3-propanediamin e (I-123-HIPDM) as the radiopharmaceutical. SPECT scans were compared with computed tomographic (CT) scans. SPECT was as sensitive as CT in detecting cerebral infarction (94% vs. 84%). The abnormalities were larger on the SPECT scans than on the CT scans in 19 cases, equal in seven, and smaller in five (SPECT abnormalities greater than or equal to CT abnormalities in 86% of cases). Fifteen of 30 patients with hemispheric infarction had decreased perfusion (decreased uptake of I-123-HIPDM) to the cerebellar hemisphere contralateral to the cerebral hemisphere involved by the infarction (crossed cerebellar diaschisis). Nine of these 15 patients had major motor deficits, while only one of the 15 without crossed cerebellar diaschisis had a major motor deficit.
对31例脑梗死患者和13例曾有短暂性脑缺血发作的患者进行了单光子发射计算机断层扫描（SPECT），使用碘-123标记的N，N，N'-三甲基-N'-(2-羟基-3-甲基-5-碘苄基)-1,3-丙二胺（I-123-HIPDM）作为放射性药物。将SPECT扫描结果与计算机断层扫描（CT）结果进行比较。在检测脑梗死方面，SPECT与CT的敏感性相同（分别为94%和84%）。19例患者SPECT扫描显示的异常区域大于CT扫描，7例两者相等，5例SPECT扫描显示的异常区域小于CT扫描（86%的病例SPECT异常大于或等于CT异常）。30例半球梗死患者中有15例对侧小脑半球灌注减少（I-123-HIPDM摄取减少）（交叉性小脑失联络）。这15例患者中有9例存在严重运动功能缺损，而15例无交叉性小脑失联络的患者中只有1例存在严重运动功能缺损。
