Shih W J, Coupal J J, Dillon M L, Kung H F
VA Medical Center, Lexington, KY.
Eur J Nucl Med. 1988;14(1):21-4. doi: 10.1007/BF00252612.
N,N,N'-Trimethyl-N'-(2-Hydroxyl-3-Methyl-5-123I Iodobenzyl)-1,3-Propanediamine.Hcl (123I-HIPDM) has been used for diagnosis of patients with strokes and dementias. Since this radiopharmaceutical is also accumulated in the lung, we routinely performed a lung image or images immediately prior to cerebral planar and SPECT images after a 3-5 mCi 123I-HIPDM injection. During the past 14 months, we obtained 78 (age from 41 to 92 years, average 66.7 +/- 8.9 years; 64 males, 14 females) suspected stroke or dementia patients' lung images. All lung images were correlated to chest X-ray (CXR) or CT and other clinical data. Sixty five of 78 patients had normal lungs showing homogeneous distribution of activity throughout the lungs which correlated well to normal CXR and/or CT studies. Abnormal scintigraphic patterns of the 13 patients included lung defect (5 bronchogenic carcinoma with or without atelectasis) and decreased uptake in apices (8 chronic obstructive pulmonary disease). The findings of pulmonary intrathoracic pathologies on lung images with 123I-HIPDM suggests further evaluation of the agent for detection of localized pulmonary diseases and pulmonary physiological studies relating to amine metabolism.
N,N,N'-三甲基-N'-(2-羟基-3-甲基-5-¹²³I 碘苄基)-1,3-丙二胺盐酸盐（¹²³I-HIPDM）已用于中风和痴呆患者的诊断。由于这种放射性药物也会在肺部蓄积，我们在注射3-5毫居里的¹²³I-HIPDM后，通常会在进行脑部平面和SPECT图像检查之前立即进行肺部图像检查。在过去的14个月里，我们获取了78例（年龄从41岁到92岁，平均66.7±8.9岁；男性64例，女性14例）疑似中风或痴呆患者的肺部图像。所有肺部图像均与胸部X线（CXR）或CT以及其他临床数据相关联。78例患者中有65例肺部正常，表现为肺部放射性均匀分布，这与正常的CXR和/或CT检查结果相关性良好。13例患者的异常闪烁显像模式包括肺部缺损（5例支气管源性癌伴或不伴肺不张）和肺尖部摄取减少（8例慢性阻塞性肺疾病）。¹²³I-HIPDM肺部图像上的肺内胸腔病变表现提示，需要进一步评估该药物在检测局限性肺部疾病以及与胺代谢相关的肺部生理学研究中的应用。
