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二烯丙基三硫醚对不同遗传背景三阴性乳腺癌细胞 TNF-α 诱导的 CCL2/MCP-1 释放的影响。

Effect of Diallyl Trisulfide on TNF-α-induced CCL2/MCP-1 Release in Genetically Different Triple-negative Breast Cancer Cells.

机构信息

Division of Pharmaceutical Sciences, College of Pharmacy and Pharmaceutical Sciences, Institute of Public Health, Florida A&M University, Tallahassee, FL, U.S.A.

出版信息

Anticancer Res. 2021 Dec;41(12):5919-5933. doi: 10.21873/anticanres.15411.

DOI:10.21873/anticanres.15411
PMID:34848446
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8691120/
Abstract

BACKGROUND/AIM: Diallyl trisulfide (DATS) has been shown to prevent and inhibit breast carcinogenesis. CCL2/MCP-1 has been shown to play a significant role in breast cancer. This study explored DATS efficacy on triple-negative breast cancer (TNBC) cells.

MATERIALS AND METHODS

DATS efficacy on TNF-α induced TNBC cells were examined via trypan blue exclusion test, wound-healing assay, human cytokine arrays, ELISA, and RT-PCR.

RESULTS

DATS significantly induced cell death and inhibited cell migration. Expression of CCL2/MCP-1, IL-6, PDGF-BB, NT-3, and GM-CSF in TNF-α-treated cells increased. However, DATS significantly decreased the expression of CCL2/MCP-1 in TNF-α-treated MDA-MB-231 but not in MDA-MB-468 cells. DATS significantly down-regulated mRNA expression of IKBKE and MAPK8 in both cell lines, indicating a possible effect in genes involved in the NF-κB and MAPK signaling.

CONCLUSION

DATS may have a role in TNBC therapy and prevention by targeting CCL2.

摘要

背景/目的：二烯丙基三硫（DATS）已被证明可预防和抑制乳腺癌的发生。趋化因子配体 2/单核细胞趋化蛋白-1（CCL2/MCP-1）已被证明在乳腺癌中发挥重要作用。本研究探讨了 DATS 对三阴性乳腺癌（TNBC）细胞的疗效。

材料与方法

通过台盼蓝排斥试验、划痕愈合试验、人细胞因子阵列、ELISA 和 RT-PCR 检测 DATS 对 TNF-α诱导的 TNBC 细胞的疗效。

结果

DATS 显著诱导细胞死亡并抑制细胞迁移。TNF-α处理的细胞中 CCL2/MCP-1、IL-6、PDGF-BB、NT-3 和 GM-CSF 的表达增加。然而，DATS 显著降低了 TNF-α处理的 MDA-MB-231 细胞中 CCL2/MCP-1 的表达，但对 MDA-MB-468 细胞无影响。DATS 显著下调了两条细胞系中 IKBKE 和 MAPK8 的 mRNA 表达，表明其可能作用于 NF-κB 和 MAPK 信号通路相关基因。

结论

DATS 可能通过靶向 CCL2 发挥作用，从而在 TNBC 的治疗和预防中发挥作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a88c/8691120/44c0195fc1b2/nihms-1762576-f0009.jpg
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