糠酸莫米松治疗儿童哮喘的疗效：一项随机对照试验的荟萃分析。
The efficacy of mometasone furoate for children with asthma: a meta-analysis of randomized controlled trials.
作者信息
Song Yanling, Pan Kaiyu, Chen Yuyan, Wang Xiaoming, Tian Jun
机构信息
Department of Paediatrics, The First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, Zhejiang Province, China.
Department of Paediatrics, The First People's Hospital of Xiaoshan, Hangzhou, Zhejiang Province, China.
出版信息
Postepy Dermatol Alergol. 2021 Oct;38(5):740-745. doi: 10.5114/ada.2020.93273. Epub 2020 Feb 25.
INTRODUCTION
The influence of mometasone furoate for paediatric asthma remains controversial.
AIM
We conducted a systematic review and meta-analysis to explore the efficacy and safety of mometasone furoate for paediatric asthma.
MATERIAL AND METHODS
We have searched PubMed, Embase, Web of science, EBSCO, and Cochrane library databases through October 2019 for randomized controlled trials assessing the effect of mometasone furoate versus placebo for paediatric asthma. This meta-analysis was performed using the random-effects model.
RESULTS
Four RCTs were included in the meta-analysis. Overall, as compared to placebo for paediatric asthma, mometasone furoate is associated with substantially increased predicted forced expiratory volume in 1 s (FEV) (mean difference (MD) = 7.53; 95% CI: 7.02-8.04; < 0.00001), FEV (MD = 0.11; 95% CI: 0.10-0.12; < 0.00001), and morning peak expiratory flow (AM PEF) (MD = 17.70; 95% CI: 9.91-25.49; < 0.00001), but demonstrates no obvious effect on pharyngitis (RR = 0.96; 95% CI: 0.59-1.58; = 0.89), upper respiratory tract infections (RR = 0.73; 95% CI: 0.50-1.05; = 0.09), or adverse events (RR = 1.05; 95% CI: 0.84-1.31; = 0.69).
CONCLUSIONS
Mometasone furoate may be effective and safe for paediatric asthma.
引言
糠酸莫米松对小儿哮喘的影响仍存在争议。
目的
我们进行了一项系统评价和荟萃分析，以探讨糠酸莫米松治疗小儿哮喘的有效性和安全性。
材料与方法
我们检索了截至2019年10月的PubMed、Embase、科学网、EBSCO和Cochrane图书馆数据库，以查找评估糠酸莫米松与安慰剂治疗小儿哮喘效果的随机对照试验。本荟萃分析采用随机效应模型。
结果
荟萃分析纳入了四项随机对照试验。总体而言，与安慰剂治疗小儿哮喘相比，糠酸莫米松与1秒用力呼气容积（FEV）显著增加相关（平均差（MD）=7.53；95%置信区间：7.02-8.04；P<0.00001）、FEV（MD=0.11；95%置信区间：0.10-0.12；P<0.00001）和早晨呼气峰值流速（AM PEF）（MD=17.70；95%置信区间：9.91-25.49；P<0.00001），但对咽炎（RR=0.96；95%置信区间：0.59-1.58；P=0.89）、上呼吸道感染（RR=0.73；95%置信区间：0.50-1.05；P=0.09）或不良事件（RR=1.05；95%置信区间：0.84-1.31；P=0.69）无明显影响。
结论
糠酸莫米松治疗小儿哮喘可能有效且安全。
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