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高剂量拉莫三嗪与苯妥英钠同时起始治疗后出现的拉莫三嗪诱导的中性粒细胞减少症。

Lamotrigine-induced neutropenia after high-dose concomitant initiation with phenytoin.

作者信息

Salem Muhammad, El-Bardissy Ahmed

机构信息

Department of Clinical Pharmacy Hamad General Hospital Doha Qatar.

出版信息

Clin Case Rep. 2021 Nov 22;9(11):e05136. doi: 10.1002/ccr3.5136. eCollection 2021 Nov.

DOI:10.1002/ccr3.5136
PMID:34849233
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8607801/
Abstract

Lamotrigine has been repeatedly reported to cause hematologic toxicities, which may be associated with high initial doses or excessive escalation. A 29-year-old lady experienced profound neutropenia after two weeks of lamotrigine high initial dose, started within two days of phenytoin. The too-early dose intensification may have produced lamotrigine-induced blood dyscrasia.

摘要

反复有报道称拉莫三嗪会引起血液学毒性，这可能与高初始剂量或过度增量有关。一名29岁女性在拉莫三嗪高初始剂量治疗两周后出现严重中性粒细胞减少，该治疗在苯妥英钠治疗开始两天内启动。过早的剂量强化可能导致了拉莫三嗪诱发的血液系统疾病。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0ae8/8607801/a107caabddcd/CCR3-9-e05136-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0ae8/8607801/a107caabddcd/CCR3-9-e05136-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0ae8/8607801/a107caabddcd/CCR3-9-e05136-g001.jpg

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Br J Clin Pharmacol. 2019 Aug;85(8):1859-1860. doi: 10.1111/bcp.13973. Epub 2019 May 29.
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Lamotrigine-Valproic Acid Interaction Leading to Stevens-Johnson Syndrome.拉莫三嗪与丙戊酸相互作用导致史蒂文斯-约翰逊综合征。
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