Department of Psychiatry, and Behavioral Science, Seoul National University College of Medicine, Seoul, Korea.
Psychiatry Investig. 2008 Jun;5(2):121-3. doi: 10.4306/pi.2008.5.2.121. Epub 2008 Jun 30.
Several psychotropic drugs, including clozapine, are known to cause agranulocytosis and this may lead to a fatal condition. Lamotrigine is an anticonvulsant that the Food and Drug Administration (FDA) has approved for the depression of bipolar disorder. A few cases of lamotrigine-induced agranulocytosis have been previously reported on, but the pathophysiology and clinical manifestations are not yet known. This case series reports on 3 patients with different medical conditions who experienced agranulocytosis during treatment with lamotrigine. In these cases, the agranulocytosis occurred a few weeks after initiation of lamotrigine and it rapidly disappeared after discontinuation. We also discuss several characteristics of lamotrigine-induced agranulocytosis.
几种精神药物，包括氯氮平，已知可引起粒细胞缺乏症，这可能导致致命的情况。拉莫三嗪是一种抗惊厥药，食品和药物管理局（FDA）已批准用于治疗双相情感障碍的抑郁症。以前曾有报道过几例拉莫三嗪引起的粒细胞缺乏症，但病理生理学和临床表现尚不清楚。本病例系列报告了 3 例患有不同疾病的患者，他们在使用拉莫三嗪治疗期间发生了粒细胞缺乏症。在这些情况下，粒细胞缺乏症在开始使用拉莫三嗪几周后发生，并在停药后迅速消失。我们还讨论了拉莫三嗪引起的粒细胞缺乏症的几个特征。
