Martinez Mariela, Kotamarti Srinath, Schulman Ariel, Mooppan Unni, Wang Jen
Division of Urology, Maimonides Research Center, Brooklyn, NY, USA.
Division of Urology, Brookdale Hospital Medical Center, Brooklyn, NY, USA.
Urol Case Rep. 2021 Sep 20;40:101835. doi: 10.1016/j.eucr.2021.101835. eCollection 2022 Jan.
We report the rare case of a primary malignant melanoma of the urethra. An 89-year-old African American woman who was referred to our urology clinic for intermittent gross hematuria and a palpable vaginal mass of two months duration. Cystoscopy revealed a 3 cm mass in the distal urethra and urethral meatus that was surgically resected by wide local excision. The histopathologic diagnosis was primary malignant melanoma of the urethra. The patient was subsequently treated with adjuvant EBRT and immunotherapy with nivolumab and ipilimumab. Post-treatment PET-CT showed good response to treatment and patient remained in remission at eight month follow up.
我们报告了一例罕见的原发性尿道恶性黑色素瘤病例。一名89岁的非裔美国女性因间歇性肉眼血尿和持续两个月可触及的阴道肿物被转诊至我们的泌尿外科诊所。膀胱镜检查发现尿道远端和尿道口有一个3厘米的肿物，通过广泛局部切除进行了手术切除。组织病理学诊断为原发性尿道恶性黑色素瘤。该患者随后接受了辅助性体外放射治疗（EBRT）以及纳武单抗和伊匹单抗免疫治疗。治疗后的PET-CT显示对治疗反应良好，患者在八个月的随访中仍处于缓解状态。
