Djafari Anahita Ansari, Seifi Poor Mohammad, Samenezhad Sina, Nicknama Reza, Rakhshan Azadeh
Laser Application in Medical Sciences Research Center, Department of Urology, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Department of Urology, Shohada-e-Tajrish Educational Hospital, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Urol Case Rep. 2025 Jul 22;62:103133. doi: 10.1016/j.eucr.2025.103133. eCollection 2025 Sep.
A 61y/o woman who presented with a dark, bleeding mass at the urethral meatus, accompanied by dysuria and significant weight loss. Initial diagnosis by a GP suggested a urethral caruncle. Imaging revealed a urethral mass, which was surgically excised. Histopathological examination confirmed the diagnosis of malignant melanoma. Despite complete surgical resection, follow-up imaging 6 months later revealed widespread metastases. She was referred for systemic and immunotherapy. This case underscores the importance of considering urethral melanoma in the differential diagnosis of urethral masses, especially when the presentation mimics benign conditions. Early recognition, thorough staging and prompt intervention are crucial for improving outcomes.
一名61岁女性，尿道口出现深色、出血性肿物，伴有排尿困难和明显体重减轻。全科医生初步诊断为尿道肉阜。影像学检查发现尿道肿物，遂进行手术切除。组织病理学检查确诊为恶性黑色素瘤。尽管手术完全切除，但6个月后的随访影像学检查显示广泛转移。她被转诊接受全身治疗和免疫治疗。该病例强调了在尿道肿物的鉴别诊断中考虑尿道黑色素瘤的重要性，尤其是当临床表现类似良性疾病时。早期识别、全面分期和及时干预对于改善预后至关重要。
