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C24:0可避免冷暴露诱导的氧化应激和脂肪酸β-氧化损伤。

C24:0 avoids cold exposure-induced oxidative stress and fatty acid β-oxidation damage.

作者信息

Sun Shouxiang, Cao Xiaojuan, Gao Jian

机构信息

College of Fisheries, Key Lab of Freshwater Animal Breeding, Ministry of Agriculture, Huazhong Agricultural University, No.1 Shizishan Stress, Hongshan District, Wuhan 430070, Hubei Province, China.

College of Fisheries, Engineering Research Center of Green Development for Conventional Aquatic Biological Industry in the Yangtze River Economic Belt, Ministry of Education/Hubei Provincial Engineering Laboratory for Pond Aquaculture, Huazhong Agricultural University, Wuhan 430070, China.

出版信息

iScience. 2021 Nov 9;24(12):103409. doi: 10.1016/j.isci.2021.103409. eCollection 2021 Dec 17.

DOI:10.1016/j.isci.2021.103409
PMID:34849471
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8607208/
Abstract

Low temperatures can cause severe growth inhibition and mortality in fish. Previous studies about the cold resistance of fish mainly focused on the role of unsaturated fatty acids, rather than saturated fatty acids (SFAs). In this study, the role of very-long-chain SFA synthetized by fatty acyl elongase 1 gene () in cold resistance was explored. Both an aggravated liver oxidative stress and a mitochondrial metabolism disorder were observed in and zebrafish with cold stress. studies confirmed that high levels of C20:0 and C22:0 obviously increased the hepatocyte oxidative stress and activated the extracellular signal-regulated kinases 1/2 (Erk1/2) pathway to further induce apoptosis and inflammation. We further demonstrated that C24:0 could promote mitochondrial β-oxidation to improve the cold resistance of zebrafish. Overall, our results define a positive role of C24:0 fatty acids synthetized by in the cold resistance of fish.

摘要

低温会导致鱼类严重生长抑制和死亡。先前关于鱼类抗寒能力的研究主要集中在不饱和脂肪酸的作用上，而非饱和脂肪酸（SFAs）。在本研究中，探讨了由脂肪酸延长酶1基因（）合成的超长链SFA在抗寒中的作用。在遭受冷应激的和斑马鱼中均观察到肝脏氧化应激加剧和线粒体代谢紊乱。研究证实，高水平的C20:0和C22:0明显增加了肝细胞氧化应激，并激活细胞外信号调节激酶1/2（Erk1/2）通路，进而诱导细胞凋亡和炎症。我们进一步证明，C24:0可促进线粒体β-氧化，从而提高斑马鱼的抗寒能力。总体而言，我们的结果确定了由合成的C24:0脂肪酸在鱼类抗寒中的积极作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7a22/8607208/ec399fa67335/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7a22/8607208/206d7fa6645e/fx1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7a22/8607208/4030800875d0/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7a22/8607208/6756726deee1/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7a22/8607208/0679449b078f/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7a22/8607208/d0b7c3c4783a/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7a22/8607208/ec399fa67335/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7a22/8607208/206d7fa6645e/fx1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7a22/8607208/4030800875d0/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7a22/8607208/6756726deee1/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7a22/8607208/0679449b078f/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7a22/8607208/d0b7c3c4783a/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7a22/8607208/ec399fa67335/gr5.jpg

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J Ethnopharmacol. 2020 Aug 10;258:112881. doi: 10.1016/j.jep.2020.112881. Epub 2020 Apr 18.
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