University of California, Riverside, USA.
Akron General Health System, OH, USA.
J Investig Med High Impact Case Rep. 2021 Jan-Dec;9:23247096211052180. doi: 10.1177/23247096211052180.
Hemophagocytic lymphohistiocytosis (HLH) is a rare and life-threatening condition that is characterized by an overactive response of the immune system with excessive production of proinflammatory cytokines. Initial presentation of this condition often mimics and overlaps with many diseases including infections, sepsis, and multiorgan failure syndrome, which makes diagnosis the diagnosis of HLH challenging. Herein is described a case of a patient who developed acute respiratory distress syndrome and multiple organ failure related to HLH in a setting of probable viral pneumonia. The diagnosis was established based on laboratory and bone marrow biopsy findings. This patient was treated with the standard chemotherapy regimen of intravenous dexamethasone, etoposide in addition to intrathecal methotrexate for central nervous system involvement.
噬血细胞性淋巴组织细胞增生症（HLH）是一种罕见且危及生命的病症，其特征是免疫系统过度活跃，过度产生促炎细胞因子。这种病症的初始表现常类似于许多疾病，包括感染、败血症和多器官衰竭综合征，这使得 HLH 的诊断具有挑战性。本文描述了一例患者，该患者在可能患有病毒性肺炎的情况下发生与 HLH 相关的急性呼吸窘迫综合征和多器官衰竭。该诊断基于实验室和骨髓活检结果。该患者接受了标准的化疗方案，包括静脉注射地塞米松、依托泊苷，以及鞘内注射甲氨蝶呤治疗中枢神经系统受累。
