Yun Li, Wang Lining, Pan Yalan, Liu Mengmin, Han Qiuge, Sun Jie, Yang Guanglu, Xiao Jirimutu, Guo Yang, Ma Yong
Laboratory of New Techniques of Restoration and Reconstruction, Institute of Traumatology and Orthopedics, Nanjing University of Chinese Medicine, China, Nanjing, China.
School of Chinese Medicine, School of Integrated Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing, China.
Folia Histochem Cytobiol. 2021;59(4):203-211. doi: 10.5603/FHC.a2021.0024. Epub 2021 Dec 1.
The occurrence of osteoporosis (OP) has drawn considerable attention from scholars around the world due to the significant impacts thereof on the social economy and the quality of human life. OP research has been rapidly expanding since the inclusion of microRNAs (miRNAs) as critical regulators of gene-expression. However, despite the ability to evaluate miRNA gene therapy in OP being enhanced, there has been a scarcity of updated citation analyses that reflect such developments. In the present study, through bibliometric analysis, the global research activity and trends in regard to the relationship between OP and miRNAs were reviewed.
Publications related to miRNA and OP from 2000 to 2021 were retrieved via Web of Science (WoS). The data included publication years, countries, journals, institutions, authors and keywords, and were sorted and summarized by bibliometrics, before being visually analyzed through VOS Viewer.
In the past five years, 599 articles have been published, with said studies accounting for 79.11% of all relevant documents, indicating the increased interest in the present research topic. The country with the highest contribution rate was China, and the publication rate of Journal of Bone and Mineral Research was the highest, followed by Bone. The institutions with the highest contribution rate were Nanjing Medical University. The most frequently occurring keywords were clustered into five groups. The research area of the first group described that circulating miRNA would be a potential biomarker for postmenopausal osteoporosis (PMOP). The remaining four groups involved the influences of miRNAs and exosomes on the osteogenic and adipogenic differentiation of mesenchymal stem cells (MSCs), and the interactions of lncRNA and miRNA with OP.
The results of the present study will expand the research on miRNAs and OP. The research direction with the highest frequency was the miRNAs acting on osteoblasts and osteoclasts. The influence of miRNAs carried by exosomes on the differentiation of MSCs might become an effective method for OP cell-free treatment.
骨质疏松症（OP）的发生因其对社会经济和人类生活质量的重大影响而引起了全球学者的广泛关注。自从将微小RNA（miRNA）作为基因表达的关键调节因子纳入研究以来，OP研究一直在迅速扩展。然而，尽管评估miRNA基因疗法治疗OP的能力有所增强，但缺乏反映此类进展的最新引文分析。在本研究中，通过文献计量分析，回顾了全球关于OP与miRNA之间关系的研究活动和趋势。
通过科学网（WoS）检索2000年至2021年期间与miRNA和OP相关的出版物。数据包括出版年份、国家、期刊、机构、作者和关键词，并通过文献计量学进行分类和总结，然后通过VOS Viewer进行可视化分析。
在过去五年中，共发表了599篇文章，这些研究占所有相关文献的79.11%，表明当前对该研究主题的兴趣有所增加。贡献率最高的国家是中国，《骨与矿物质研究杂志》的发表率最高，其次是《骨》。贡献率最高的机构是南京医科大学。出现频率最高的关键词被聚类为五组。第一组的研究领域表明，循环miRNA可能是绝经后骨质疏松症（PMOP）的潜在生物标志物。其余四组涉及miRNA和外泌体对间充质干细胞（MSC）成骨和成脂分化的影响，以及长链非编码RNA和miRNA与OP的相互作用。
本研究结果将拓展对miRNA与OP的研究。出现频率最高的研究方向是miRNA作用于成骨细胞和破骨细胞。外泌体携带的miRNA对MSC分化的影响可能成为OP无细胞治疗的有效方法。
