Graduate School, Tianjin University of Traditional Chinese Medicine, Tianjin, China.
College of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, China.
Medicine (Baltimore). 2023 Sep 29;102(39):e35381. doi: 10.1097/MD.0000000000035381.
Currently, theoretical studies on exosomes in respiratory diseases have received much attention from many scholars and have made remarkable progress, which has inestimable value and potential in future clinical and scientific research. Unfortunately, no scholar has yet addressed this field's bibliometric analysis and summary. We aim to comprehensively and profoundly study and explore the present situation and highlights of exosome research at the stage of respiratory diseases and to provide meaningful insights for the future development of this field. The WOSCC literature was gathered for the study using bibliometrics, and the data were collected and analyzed using CiteSpace, VOSviewer, Microsoft Excel, and Endnote software. The publication language is "English," and the search strategy is TS = (exosome OR exosomes OR exosomal) AND TS = (respiratory OR lung). The search time is from the beginning of the WOS construction, and the deadline is July 11, 2022, at 22:00 hours. The literature types selected were dissertation, review paper, and online published paper. The analysis includes 2456 publications in 738 journals from 76 countries, 2716 institutions, and 14,568 authors. The field's annual publications have been rising, especially in recent years. China and the US lead research, and prominent universities, including Harvard Medical School, Shanghai Jiao Tong University, and Fudan University, are essential research institutes. Takahiro Ochiya, whose research focuses on exosomes and lung cancer, and Clotilde Théry, a pioneering exosome researcher, are the most cited authors in this field. The key terms include lung cancer, non-small cell lung cancer, mesenchymal stem cells, intercellular communication, exosomal miRNAs, and oncology. Cell biology, biochemistry & biotechnology, and oncology are related fields. The final summary of research hotspots is exosomes and lung cancer, mesenchymal stem cell-derived exosomes and lung inflammation, and miRNAs in exosomes as biomarkers for respiratory illnesses. The present research situation and relevant hotspots of the area were analyzed through bibliometric studies on exosomes in respiratory diseases. The research development in this field has a considerable upside, and the exosome's function in diagnosing, treating, monitoring, and prognosis of respiratory illnesses cannot be taken lightly. Moreover, we believe the research results will bring the gospel to many patients with clinical respiratory diseases shortly.
目前，呼吸疾病中外泌体的理论研究受到了众多学者的关注，并取得了显著进展，这在未来的临床和科学研究中具有不可估量的价值和潜力。遗憾的是，目前还没有学者对该领域进行文献计量分析和总结。我们旨在全面深入地研究和探讨呼吸疾病中外泌体研究的现状和热点，为该领域的未来发展提供有意义的见解。本研究采用文献计量学方法收集 WOSCC 文献，使用 CiteSpace、VOSviewer、Microsoft Excel 和 Endnote 软件进行数据收集和分析。文献出版语言为“英语”，检索策略为 TS=（外泌体或外泌体或外泌体）和 TS=（呼吸或肺）。检索时间为 WOS 构建开始时间，截止日期为 2022 年 7 月 11 日 22 点。选择的文献类型包括学位论文、综述论文和在线发表论文。分析包括来自 76 个国家的 738 种期刊的 2456 篇文献，涉及 2716 个机构和 14568 名作者。该领域的年度出版物一直在增加，尤其是近年来。中国和美国引领着研究，哈佛大学医学院、上海交通大学和复旦大学等著名大学是重要的研究机构。研究重点是外泌体和肺癌的 Takahiro Ochiya 和外泌体研究的先驱者 Clotilde Théry 是该领域被引最多的作者。关键术语包括肺癌、非小细胞肺癌、间充质干细胞、细胞间通讯、外泌体 miRNAs 和肿瘤学。细胞生物学、生物化学与生物技术和肿瘤学是相关领域。通过对呼吸疾病中外泌体的文献计量学研究，最终总结了研究热点为外泌体与肺癌、间充质干细胞衍生的外泌体与肺炎症、外泌体中的 miRNAs 作为呼吸疾病的生物标志物。通过对呼吸疾病中外泌体的文献计量学研究，分析了该领域的研究现状及相关热点。该领域的研究发展潜力巨大，外泌体在诊断、治疗、监测和预测呼吸疾病方面的作用不容忽视。此外，我们相信研究结果将很快给许多患有临床呼吸系统疾病的患者带来福音。
